The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F23%3A10003392" target="_blank" >RIV/27661989:_____/23:10003392 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/ecco-jcc/article/17/Supplement_1/i1023/7010319" target="_blank" >https://academic.oup.com/ecco-jcc/article/17/Supplement_1/i1023/7010319</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ecco-jcc/jjac190.1041" target="_blank" >10.1093/ecco-jcc/jjac190.1041</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin

Popis výsledku v původním jazyce

This study evaluated changes in the faecal microbiome and metabolome after anti‑TNFα therapy in children with Crohn’s disease (CD) and compared them with children diagnosed with juvenile idiopathic arthritis (JIA), a condition that rarely affects the intestine. A total of 530 stool samples were analysed using 16S rRNA V4 region sequencing and ¹H NMR metabolomics. Anti‑TNFα therapy in CD led to a significant reduction in faecal calprotectin and induced specific microbial and metabolite changes that were not observed in JIA. In CD, the abundances of Blautia, Ruminococcus, Intestinibacter and Erysipelatoclostridium increased, whereas Allistipes decreased. Among metabolites, glucose and glycerol increased, while isoleucine and uracil decreased. The findings indicate that the microbiome shifts following anti‑TNFα therapy are secondary to the improvement of intestinal inflammation.

Název v anglickém jazyce

The changes in the faecal microbiome and metabolome in Crohn's disease after treatment with anti-TNF(sic) antibodies are of secondary origin

Popis výsledku anglicky

This study evaluated changes in the faecal microbiome and metabolome after anti‑TNFα therapy in children with Crohn’s disease (CD) and compared them with children diagnosed with juvenile idiopathic arthritis (JIA), a condition that rarely affects the intestine. A total of 530 stool samples were analysed using 16S rRNA V4 region sequencing and ¹H NMR metabolomics. Anti‑TNFα therapy in CD led to a significant reduction in faecal calprotectin and induced specific microbial and metabolite changes that were not observed in JIA. In CD, the abundances of Blautia, Ruminococcus, Intestinibacter and Erysipelatoclostridium increased, whereas Allistipes decreased. Among metabolites, glucose and glycerol increased, while isoleucine and uracil decreased. The findings indicate that the microbiome shifts following anti‑TNFα therapy are secondary to the improvement of intestinal inflammation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Crohn&apos;s and Colitis

ISSN

1873-9946

e-ISSN

1876-4479

Svazek periodika

17

Číslo periodika v rámci svazku

Supplement 1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

1023-1024

Kód UT WoS článku

000960367602135

EID výsledku v databázi Scopus

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