Anatomy and pathophysiology of nAMD
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003214" target="_blank" >RIV/27661989:_____/25:10003214 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Anatomy and pathophysiology of nAMD
Popis výsledku v původním jazyce
The lecture presented at the Vision+ expert-led webinar on Neovascular Age-Related Macular Degeneration focused on the detailed anatomy of the macula's central retina and the pathophysiological mechanisms leading to the development of neovascular (wet) age-related macular degeneration (nAMD). It discussed the roles of the retinal pigment epithelium, Bruch's membrane, and the choriocapillaris in maintaining macular integrity and how age-related changes in these structures facilitate neovascularization. Neovascular AMD is characterized by the abnormal growth of new blood vessels from the choroid into the subretinal space, whose leakiness leads to exudation, edema, hemorrhage, and subsequent photoreceptor damage with rapid central vision loss. The pathophysiology involves complex interactions among oxidative stress, inflammatory processes, genetic predispositions, and pathological angiogenesis driven primarily by vascular endothelial growth factor (VEGF). Understanding these mechanisms is critical for diagnosis, prognosis, and development of targeted therapeutic strategies.
Název v anglickém jazyce
Anatomy and pathophysiology of nAMD
Popis výsledku anglicky
The lecture presented at the Vision+ expert-led webinar on Neovascular Age-Related Macular Degeneration focused on the detailed anatomy of the macula's central retina and the pathophysiological mechanisms leading to the development of neovascular (wet) age-related macular degeneration (nAMD). It discussed the roles of the retinal pigment epithelium, Bruch's membrane, and the choriocapillaris in maintaining macular integrity and how age-related changes in these structures facilitate neovascularization. Neovascular AMD is characterized by the abnormal growth of new blood vessels from the choroid into the subretinal space, whose leakiness leads to exudation, edema, hemorrhage, and subsequent photoreceptor damage with rapid central vision loss. The pathophysiology involves complex interactions among oxidative stress, inflammatory processes, genetic predispositions, and pathological angiogenesis driven primarily by vascular endothelial growth factor (VEGF). Understanding these mechanisms is critical for diagnosis, prognosis, and development of targeted therapeutic strategies.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30207 - Ophthalmology
Návaznosti výsledku
Projekt
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Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů