Prevalence, Causal Classification, and Prognosis of Patent Foramen Ovale in Young Patients With Embolic Strokes of Undetermined Source

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003307" target="_blank" >RIV/27661989:_____/25:10003307 - isvavai.cz</a>

Výsledek na webu

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12184216/pdf/JAH3-14-e038948.pdf" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC12184216/pdf/JAH3-14-e038948.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/JAHA.124.038948" target="_blank" >10.1161/JAHA.124.038948</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence, Causal Classification, and Prognosis of Patent Foramen Ovale in Young Patients With Embolic Strokes of Undetermined Source

Popis výsledku v původním jazyce

This research letter published in the Journal of the American Heart Association assessed the prevalence of patent foramen ovale (PFO), its likely causal role in embolic stroke of undetermined source (ESUS), and prognosis in young patients. The analysis used the multicenter prospective Y-ESUS cohort (13 countries; enrollment 2017–2019) including patients ≤50 years with recent ESUS, restricted to those with TEE-confirmed PFO and sufficient anatomic detail for PASCAL classification (probable/possible/unlikely PFO-related stroke). PFO was frequent in the registry (≈50%), and most cases were categorized as probable or possible by PASCAL (≈85%). Over a median follow-up of ~18 months, no recurrent ischemic strokes occurred among patients with PFO; PFO closure was performed in roughly one-third and appeared only weakly related to estimated PFO pathogenicity. Overall, the findings support a high prevalence of PFO in young ESUS and suggest a low short-term recurrence risk, while highlighting limitations due to variable echocardiography protocols and incomplete TEE ascertainment in part of the cohort.

Název v anglickém jazyce

Prevalence, Causal Classification, and Prognosis of Patent Foramen Ovale in Young Patients With Embolic Strokes of Undetermined Source

Popis výsledku anglicky

This research letter published in the Journal of the American Heart Association assessed the prevalence of patent foramen ovale (PFO), its likely causal role in embolic stroke of undetermined source (ESUS), and prognosis in young patients. The analysis used the multicenter prospective Y-ESUS cohort (13 countries; enrollment 2017–2019) including patients ≤50 years with recent ESUS, restricted to those with TEE-confirmed PFO and sufficient anatomic detail for PASCAL classification (probable/possible/unlikely PFO-related stroke). PFO was frequent in the registry (≈50%), and most cases were categorized as probable or possible by PASCAL (≈85%). Over a median follow-up of ~18 months, no recurrent ischemic strokes occurred among patients with PFO; PFO closure was performed in roughly one-third and appeared only weakly related to estimated PFO pathogenicity. Overall, the findings support a high prevalence of PFO in young ESUS and suggest a low short-term recurrence risk, while highlighting limitations due to variable echocardiography protocols and incomplete TEE ascertainment in part of the cohort.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American Heart Association

ISSN

—

e-ISSN

2047-9980

Svazek periodika

14

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

nestránkováno

Kód UT WoS článku

001482863000001

EID výsledku v databázi Scopus

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