Low fibrinogen after intravenous thrombolysis: a possible predictor of hemorrhagic intracranial complications?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003515" target="_blank" >RIV/27661989:_____/25:10003515 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/ene.70191" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/ene.70191</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ene.70191" target="_blank" >10.1111/ene.70191</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low fibrinogen after intravenous thrombolysis: a possible predictor of hemorrhagic intracranial complications?

Popis výsledku v původním jazyce

Background and aims: Current Czech guidelines for treatment with intravenous thrombolysis (IVT) include the examination of coagulation parameters, including fibrinogen levels, before IVT, 6 hours and 24 hours after IVT, but there is no official recommendation on when to substitute fibrinogen, and whether to do so at all. Substitution is available in hospitals (Hemocomplettan i.v.). Fibrinogen substitution may be a way to prevent the development of bleeding complications during IVT treatment. The aim of this study was to evaluate whether a decrease in fibrinogen levels below the reference range of 1.8 g/l is associated with a higher likelihood of intracranial hemorrhage in patients with ischemic stroke treated with IVT.Methods: This multicenter retrospective study was conducted in 7 Czech centers. The study population consists of 280 patients enrolled in the observational group (divided into subgroups according to the type of hemorrhagic complication after IVT) and the control group (without hemorrhagic complication) according to the model 1:1 principle (same NIHSS, age, sex).Results: In all treatment groups (all observational subgroups as well as the control group), a decrease in fibrinogen levels was noted after IVT administration, with varying degrees of signification. A statistically significant difference (p = 0.0394) was found at 6 h after IVT administration in patients with the most clinically serious form of bleeding (parenchymal hematoma type 2), fibrinogen value 1.84 g/l versus 2.53 g/l.

Název v anglickém jazyce

Low fibrinogen after intravenous thrombolysis: a possible predictor of hemorrhagic intracranial complications?

Popis výsledku anglicky

Background and aims: Current Czech guidelines for treatment with intravenous thrombolysis (IVT) include the examination of coagulation parameters, including fibrinogen levels, before IVT, 6 hours and 24 hours after IVT, but there is no official recommendation on when to substitute fibrinogen, and whether to do so at all. Substitution is available in hospitals (Hemocomplettan i.v.). Fibrinogen substitution may be a way to prevent the development of bleeding complications during IVT treatment. The aim of this study was to evaluate whether a decrease in fibrinogen levels below the reference range of 1.8 g/l is associated with a higher likelihood of intracranial hemorrhage in patients with ischemic stroke treated with IVT.Methods: This multicenter retrospective study was conducted in 7 Czech centers. The study population consists of 280 patients enrolled in the observational group (divided into subgroups according to the type of hemorrhagic complication after IVT) and the control group (without hemorrhagic complication) according to the model 1:1 principle (same NIHSS, age, sex).Results: In all treatment groups (all observational subgroups as well as the control group), a decrease in fibrinogen levels was noted after IVT administration, with varying degrees of signification. A statistically significant difference (p = 0.0394) was found at 6 h after IVT administration in patients with the most clinically serious form of bleeding (parenchymal hematoma type 2), fibrinogen value 1.84 g/l versus 2.53 g/l.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Neurology

ISSN

1351-5101

e-ISSN

1468-1331

Svazek periodika

32

Číslo periodika v rámci svazku

Supplement 1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

80

Kód UT WoS článku

001628319700875

EID výsledku v databázi Scopus

—