Changes of Cardiac Biomarkers in Ultramarathon Runners

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13430%2F19%3A43894721" target="_blank" >RIV/44555601:13430/19:43894721 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.physactiv.eu/wp-content/uploads/2019/01/2019_11.pdf" target="_blank" >http://www.physactiv.eu/wp-content/uploads/2019/01/2019_11.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.16926/par.2019.07.11" target="_blank" >10.16926/par.2019.07.11</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Changes of Cardiac Biomarkers in Ultramarathon Runners

Popis výsledku v původním jazyce

Introduction: The aim of this study is to examine and evaluate the effects of long-term stress on muscle and heart biomarkers after completing a 100 km ultramarathon. Material and Methods: Venous blood samples of nine runners (average age 38.8+-10.2 years), who successfully finished a 100 km ultramarathon at an elevation of 3130 m, were examined before the start, at the finish line immediately after the run, one day after the run and then after 5 and 10 days. Clinical, laboratory, and somatometric data were obtained from all measurements, and biomarkers: aspartate aminotransferase (AST), cortisol (COR), troponin T (cTnT), creatine kinase (CK) and C-reactive protein (CRP). Also, their training experience and ultramarathon experience was monitored. Discovered values were further analyzed with the use of t-test a ?2 (?2GREATER-THAN OR EQUAL TO0.1), and Spearman&apos;s rank correlation coefficient (r) at the significance level of p&lt;0.05. Results: The average finish time of the runners was 13:55:40 (min: 12:12:35, max: 16:52:02). After finishing the ultramarathon, runners showed an average weight loss of 2.4 kg (p&lt;0.05). The results show that hematological changes were caused by physiological stress and long-term physical load. The values of all monitored biomarkers showed a significant exceeding of the normal values immediately after the race in 8 competitors out of 9. The values of cTnT showed an increase of more than 50 % (pre-race: 8.2+-2.3, post-race: 34.22+-25.9 ng/l, max=98 ng/l). After 24 hours, however, this condition had returned to the normal values for all participants. The results show that the AST hepatic enzymes significantly correlated with the training experience (r=-0.41, p=0.043), the total number of kilometers run per year (r=-0.45, p=0.04) and the achieved finish time (r=0.67, p=0.001). At the same time, athletes who had the best finish time achieved lower CRP values (r=0.74, p=0.023) and cTnT values (r=0.49, p=0.040). The study found that the competitors who had the longest experience with ultramaraton had the lowest cTnT (r=0.44, p=0.050). Conclusion: Long-term physical stress is associated with metabolic and cardiovascular changes. Blood abnormalities found in our study suggest that due to long-lasting extreme stress, heart exhaustion may occur. However, these changes did not last long and after a few days they returned to the normal values for all runners.

Název v anglickém jazyce

Changes of Cardiac Biomarkers in Ultramarathon Runners

Popis výsledku anglicky

Introduction: The aim of this study is to examine and evaluate the effects of long-term stress on muscle and heart biomarkers after completing a 100 km ultramarathon. Material and Methods: Venous blood samples of nine runners (average age 38.8+-10.2 years), who successfully finished a 100 km ultramarathon at an elevation of 3130 m, were examined before the start, at the finish line immediately after the run, one day after the run and then after 5 and 10 days. Clinical, laboratory, and somatometric data were obtained from all measurements, and biomarkers: aspartate aminotransferase (AST), cortisol (COR), troponin T (cTnT), creatine kinase (CK) and C-reactive protein (CRP). Also, their training experience and ultramarathon experience was monitored. Discovered values were further analyzed with the use of t-test a ?2 (?2GREATER-THAN OR EQUAL TO0.1), and Spearman&apos;s rank correlation coefficient (r) at the significance level of p&lt;0.05. Results: The average finish time of the runners was 13:55:40 (min: 12:12:35, max: 16:52:02). After finishing the ultramarathon, runners showed an average weight loss of 2.4 kg (p&lt;0.05). The results show that hematological changes were caused by physiological stress and long-term physical load. The values of all monitored biomarkers showed a significant exceeding of the normal values immediately after the race in 8 competitors out of 9. The values of cTnT showed an increase of more than 50 % (pre-race: 8.2+-2.3, post-race: 34.22+-25.9 ng/l, max=98 ng/l). After 24 hours, however, this condition had returned to the normal values for all participants. The results show that the AST hepatic enzymes significantly correlated with the training experience (r=-0.41, p=0.043), the total number of kilometers run per year (r=-0.45, p=0.04) and the achieved finish time (r=0.67, p=0.001). At the same time, athletes who had the best finish time achieved lower CRP values (r=0.74, p=0.023) and cTnT values (r=0.49, p=0.040). The study found that the competitors who had the longest experience with ultramaraton had the lowest cTnT (r=0.44, p=0.050). Conclusion: Long-term physical stress is associated with metabolic and cardiovascular changes. Blood abnormalities found in our study suggest that due to long-lasting extreme stress, heart exhaustion may occur. However, these changes did not last long and after a few days they returned to the normal values for all runners.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30306 - Sport and fitness sciences

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physical Activity Review

ISSN

2300-5076

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

2019

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

7

Strana od-do

89-95

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85070957251