Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F12%3A43884027" target="_blank" >RIV/44555601:13440/12:43884027 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/12:43874587
Výsledek na webu
<a href="http://dx.doi.org/10.5562/cca1811" target="_blank" >http://dx.doi.org/10.5562/cca1811</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5562/cca1811" target="_blank" >10.5562/cca1811</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats
Popis výsledku v původním jazyce
The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime 1(203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. 1(203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone oroxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats.
Název v anglickém jazyce
Effects of Oxime K203 and Oxidative Stress in Plasma of Tabun Poisoned Rats
Popis výsledku anglicky
The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime 1(203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. 1(203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone oroxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GP305%2F07%2FP162" target="_blank" >GP305/07/P162: Vztah mezi strukturou reaktivátorů acetylcholinesterázy a jejich reaktivační účinností</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Croatica Chemica Acta
ISSN
0011-1643
e-ISSN
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Svazek periodika
85
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
HR - Chorvatská republika
Počet stran výsledku
7
Strana od-do
193-199
Kód UT WoS článku
000306880200010
EID výsledku v databázi Scopus
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