Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43893542" target="_blank" >RIV/44555601:13440/16:43893542 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c6ra06969j" target="_blank" >http://dx.doi.org/10.1039/c6ra06969j</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6ra06969j" target="_blank" >10.1039/c6ra06969j</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

Popis výsledku v původním jazyce

Cell surface heparan sulfate (HS) represents a common link that many sexually transmitted infections (STIs) require for infection. The role of HS is associated with several viral STIs, which include those caused by herpes simplex virus (HVS), human immunodeficiency virus (HIV), human papillomavirus (HPV) and hepatitis C virus (HCV). Nowadays, no cure has been found for any of the STIs associated with viral pathogens. In this review, we evaluate dendrimers such as peptide derivatized-dendrimers, carbosilane dendrimers, polysulfated galactose functionalized glycodendrimers and PAMAM dendrimers, among others, as potential candidates for the development of topical microbicides against viral STIs associated with HS. Subsequently, we propose the mechanism of action of these dendrimers and how it might be associated with the relevance of HS in several STIs. HS in just an ancillary factor in the case of HIV-1 infection and it plays a major role in the case of HCV, HSV-2 and HPV viruses. However, the mechanism of action presented by these dendrimers is common in all pathologies, acting at the level of viral entry into the target cell, either directly blocking the viral particles that are meant to bind to the HS or binding to cellular co-receptors.

Název v anglickém jazyce

Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate

Popis výsledku anglicky

Cell surface heparan sulfate (HS) represents a common link that many sexually transmitted infections (STIs) require for infection. The role of HS is associated with several viral STIs, which include those caused by herpes simplex virus (HVS), human immunodeficiency virus (HIV), human papillomavirus (HPV) and hepatitis C virus (HCV). Nowadays, no cure has been found for any of the STIs associated with viral pathogens. In this review, we evaluate dendrimers such as peptide derivatized-dendrimers, carbosilane dendrimers, polysulfated galactose functionalized glycodendrimers and PAMAM dendrimers, among others, as potential candidates for the development of topical microbicides against viral STIs associated with HS. Subsequently, we propose the mechanism of action of these dendrimers and how it might be associated with the relevance of HS in several STIs. HS in just an ancillary factor in the case of HIV-1 infection and it plays a major role in the case of HCV, HSV-2 and HPV viruses. However, the mechanism of action presented by these dendrimers is common in all pathologies, acting at the level of viral entry into the target cell, either directly blocking the viral particles that are meant to bind to the HS or binding to cellular co-receptors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30107 - Medicinal chemistry

Projekt

<a href="/cs/project/GA15-05903S" target="_blank" >GA15-05903S: Nové karbosilanové dendrimery pro biomedicínské aplikace - interakce s biomolekulami a biomembránami</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

2016

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

46755-46764

Kód UT WoS článku

000377254800078

EID výsledku v databázi Scopus

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