Factors affecting interactions between sulphonate-terminateddendrimers and proteins: A three case study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F17%3A43887785" target="_blank" >RIV/44555601:13440/17:43887785 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S092777651630724X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S092777651630724X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfb.2016.10.020" target="_blank" >10.1016/j.colsurfb.2016.10.020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Factors affecting interactions between sulphonate-terminateddendrimers and proteins: A three case study

Popis výsledku v původním jazyce

This work proposes a deep study on the interactions between sulphonate-terminated carbosilane den-drimers and proteins. Three different proteins with different molecular weights and isoelectric pointswere employed and different pHs, dendrimer concentrations and generations were tested. Variations influorescence intensity and emission wavelength were used as protein-dendrimer interaction probes.Interaction between dendrimers and proteins greatly depended on the protein itself and pH. Otherimportant issues were the dendrimer concentration and generation. Protein-dendrimer interactions werefavored under acidic working conditions when proteins were positively charged. Moreover, in general,high dendrimer generations promoted these interactions. Modeling of protein-dendrimer interactionsallowed to understand the different behaviors observed for every protein.

Název v anglickém jazyce

Factors affecting interactions between sulphonate-terminateddendrimers and proteins: A three case study

Popis výsledku anglicky

This work proposes a deep study on the interactions between sulphonate-terminated carbosilane den-drimers and proteins. Three different proteins with different molecular weights and isoelectric pointswere employed and different pHs, dendrimer concentrations and generations were tested. Variations influorescence intensity and emission wavelength were used as protein-dendrimer interaction probes.Interaction between dendrimers and proteins greatly depended on the protein itself and pH. Otherimportant issues were the dendrimer concentration and generation. Protein-dendrimer interactions werefavored under acidic working conditions when proteins were positively charged. Moreover, in general,high dendrimer generations promoted these interactions. Modeling of protein-dendrimer interactionsallowed to understand the different behaviors observed for every protein.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA13-06989S" target="_blank" >GA13-06989S: Plazmo-chemické modifikace fylosilikátů pro funkční nanostruktury</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces B-Biointerfaces

ISSN

0927-7765

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

149

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

196-205

Kód UT WoS článku

000390625200025

EID výsledku v databázi Scopus

—