Effect of surface decoration on properties and drug release ability of nanogels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F21%3A43896167" target="_blank" >RIV/44555601:13440/21:43896167 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.journals.elsevier.com/colloids-and-surfaces-a-physicochemical-and-engineering-aspects" target="_blank" >https://www.journals.elsevier.com/colloids-and-surfaces-a-physicochemical-and-engineering-aspects</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2021.126164" target="_blank" >10.1016/j.colsurfa.2021.126164</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of surface decoration on properties and drug release ability of nanogels

Popis výsledku v původním jazyce

Nanogels are a central class of biomaterials widely used in the field of drug delivery for the treatment of different pathologies such as tumors, cardiovascular diseases or central nervous system disorders. The great peculiarity of these systems is that, if properly surface functionalized, they are able to target specific body tissues and exploit precise targeted drug delivery. Anyway, the presence of a surface layer on the nanoparticle core can affect not only the biological behavior of the whole system but also its physical and drug delivery properties. In this work we investigated how the presence of different surface functionalization strategies on the same PEG-PEI nanogel framework influences the aforementioned peculiarities. The nanogels were functionalized with amine and pyridinic groups, while the properties analyzed and compared were the hydrodynamic diameter, the zeta-potential and the drug release ability. Moreover, we performed the evaluation of the cytocompatibility of the final nano-carrier and a molecular analysis of the surface features of these systems at microscopic level.

Název v anglickém jazyce

Effect of surface decoration on properties and drug release ability of nanogels

Popis výsledku anglicky

Nanogels are a central class of biomaterials widely used in the field of drug delivery for the treatment of different pathologies such as tumors, cardiovascular diseases or central nervous system disorders. The great peculiarity of these systems is that, if properly surface functionalized, they are able to target specific body tissues and exploit precise targeted drug delivery. Anyway, the presence of a surface layer on the nanoparticle core can affect not only the biological behavior of the whole system but also its physical and drug delivery properties. In this work we investigated how the presence of different surface functionalization strategies on the same PEG-PEI nanogel framework influences the aforementioned peculiarities. The nanogels were functionalized with amine and pyridinic groups, while the properties analyzed and compared were the hydrodynamic diameter, the zeta-potential and the drug release ability. Moreover, we performed the evaluation of the cytocompatibility of the final nano-carrier and a molecular analysis of the surface features of these systems at microscopic level.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/EF17_048%2F0007411" target="_blank" >EF17_048/0007411: UniQSurf - Centrum biopovrchů a hybridních funkčních materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces A-Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

—

Svazek periodika

614

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

126164-126173

Kód UT WoS článku

000623251700004

EID výsledku v databázi Scopus

2-s2.0-85099613888