Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13450%2F19%3A43895411" target="_blank" >RIV/44555601:13450/19:43895411 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/19:10402193 RIV/00216208:11150/19:10402193 RIV/00179906:_____/19:10402193 RIV/00669806:_____/19:10402193

Výsledek na webu

<a href="https://bmcanesthesiol.biomedcentral.com/track/pdf/10.1186/s12871-019-0896-2" target="_blank" >https://bmcanesthesiol.biomedcentral.com/track/pdf/10.1186/s12871-019-0896-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12871-019-0896-2" target="_blank" >10.1186/s12871-019-0896-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice

Popis výsledku v původním jazyce

The endothelial glycocalyx (EG) is the thin sugar-based lining on the apical surface of endothelial cells. It has been linked to the physiological functioning of the microcirculation and has been found to be damaged in critical illness and after acute care surgery. This review aims to describe the role of EG in severely injured patients undergoing surgery, discuss specific situations (e.G. major trauma, hemorrhagic shock, trauma induced coagulopathy) as well as specific interventions commonly applied in these patients (e.g. fluid therapy, transfusion) and specific drugs related to perioperative medicine with regard to their impact on EG. EG in acute care surgery is exposed to damage due to tissue trauma, inflammation, oxidative stress and inadequate fluid therapy. Even though some interventions (transfusion of plasma, human serum albumin, hydrocortisone, sevoflurane) are described as potentially EG protective there is still no specific treatment for EG protection and recovery in clinical medicine. The most important principle to be adopted in routine clinical practice at present is to acknowledge the fragile structure of the EG and avoid further damage which is potentially related to worsened clinical outcome.

Název v anglickém jazyce

Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice

Popis výsledku anglicky

The endothelial glycocalyx (EG) is the thin sugar-based lining on the apical surface of endothelial cells. It has been linked to the physiological functioning of the microcirculation and has been found to be damaged in critical illness and after acute care surgery. This review aims to describe the role of EG in severely injured patients undergoing surgery, discuss specific situations (e.G. major trauma, hemorrhagic shock, trauma induced coagulopathy) as well as specific interventions commonly applied in these patients (e.g. fluid therapy, transfusion) and specific drugs related to perioperative medicine with regard to their impact on EG. EG in acute care surgery is exposed to damage due to tissue trauma, inflammation, oxidative stress and inadequate fluid therapy. Even though some interventions (transfusion of plasma, human serum albumin, hydrocortisone, sevoflurane) are described as potentially EG protective there is still no specific treatment for EG protection and recovery in clinical medicine. The most important principle to be adopted in routine clinical practice at present is to acknowledge the fragile structure of the EG and avoid further damage which is potentially related to worsened clinical outcome.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30223 - Anaesthesiology

Projekt

<a href="/cs/project/NV15-31881A" target="_blank" >NV15-31881A: Alterace glykokalyx v kritických stavech a během velkých operačních výkonů a možnosti její protekce</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Anesthesiology

ISSN

1471-2253

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

"nestrankovano"

Kód UT WoS článku

000510512500002

EID výsledku v databázi Scopus

2-s2.0-85077012061