Modern possibilities of diagnosis and treatment of Peyronie's disease in the Czech context

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13450%2F25%3A43899521" target="_blank" >RIV/44555601:13450/25:43899521 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.prolekare.cz/casopisy/casopis-lekaru-ceskych/2025-6-4/moderni-moznosti-diagnostiky-a-lecby-peyronieho-choroby-diagnosticke-a-lecebne-moznosti-v-ceskem-kontextu-142231" target="_blank" >https://www.prolekare.cz/casopisy/casopis-lekaru-ceskych/2025-6-4/moderni-moznosti-diagnostiky-a-lecby-peyronieho-choroby-diagnosticke-a-lecebne-moznosti-v-ceskem-kontextu-142231</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/cas.2025.026" target="_blank" >10.5507/cas.2025.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modern possibilities of diagnosis and treatment of Peyronie's disease in the Czech context

Popis výsledku v původním jazyce

Peyronie&apos;s disease is an acquired fibrotic disorder of the tunica albuginea, leading to penile deformity, painful erections, and often erectile dysfunction; its prevalence in Europe reaches up to 9% in middle-aged men. This review summarizes the results of studies from 2019-2025 concerning diagnostic methods and therapeutic options. Based on the analysis of 142 original studies, 23 meta-analyses, and current European Association of Urology (EAU) a American Urological Association (AUA) recommendations, we confirm that intralesional verapamil reduces curvature in the active phase by an average of 9-17o and low-intensity shockwave therapy (LiSWT) improves pain and reduces curvature by approximately 10o, particularly for plaques larger than 2 cm. Surgical methods - plication, incision/grafting, and penile prosthesis implantation - achieve initial straightening in more than 90% of cases but differ in impact on penile length and the risk of de novo erectile dysfunction. Regenerative therapies like platelet-rich plasma (PRP) or mesenchymal stem cells (MSC) offer promising, yet currently experimental results. Optimal care is based on early diagnosis, individualization of conservative treatment, and precise surgical correction; in the Czech Republic, standard approaches include verapamil, LiSWT, and surgery, while biological approaches require further research.

Název v anglickém jazyce

Modern possibilities of diagnosis and treatment of Peyronie's disease in the Czech context

Popis výsledku anglicky

Peyronie&apos;s disease is an acquired fibrotic disorder of the tunica albuginea, leading to penile deformity, painful erections, and often erectile dysfunction; its prevalence in Europe reaches up to 9% in middle-aged men. This review summarizes the results of studies from 2019-2025 concerning diagnostic methods and therapeutic options. Based on the analysis of 142 original studies, 23 meta-analyses, and current European Association of Urology (EAU) a American Urological Association (AUA) recommendations, we confirm that intralesional verapamil reduces curvature in the active phase by an average of 9-17o and low-intensity shockwave therapy (LiSWT) improves pain and reduces curvature by approximately 10o, particularly for plaques larger than 2 cm. Surgical methods - plication, incision/grafting, and penile prosthesis implantation - achieve initial straightening in more than 90% of cases but differ in impact on penile length and the risk of de novo erectile dysfunction. Regenerative therapies like platelet-rich plasma (PRP) or mesenchymal stem cells (MSC) offer promising, yet currently experimental results. Optimal care is based on early diagnosis, individualization of conservative treatment, and precise surgical correction; in the Czech Republic, standard approaches include verapamil, LiSWT, and surgery, while biological approaches require further research.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Časopis lékařů českých

ISSN

0008-7335

e-ISSN

—

Svazek periodika

164

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

262-268

Kód UT WoS článku

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EID výsledku v databázi Scopus

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