Speciation and supersaturation of urine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13520%2F18%3A43893831" target="_blank" >RIV/44555601:13520/18:43893831 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00706-017-2115-5" target="_blank" >http://dx.doi.org/10.1007/s00706-017-2115-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-017-2115-5" target="_blank" >10.1007/s00706-017-2115-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Speciation and supersaturation of urine

Popis výsledku v původním jazyce

Thermodynamic equilibria in urine at 37 oC showed that the inorganic urinary constituents, citrate and oxalate are present as 76 different species. Complexes formed by uric acid and various organic compounds, such as creatinine, proteins, hormones and metabolites, for which the relevant thermodynamic data are not available in the library of the computer program MINTEQA2 Version 3 were not considered. The actual thermodynamic supersaturation of urine with respect to calcium oxalate monohydrate and dihydrate was calculated. The effects of varying composition of urine at the same pH and the violation of the condition of electroneutrality on the calculated supersaturation were shown. The supersaturation of urine should never be computed from incomplete data of urine composition. Incomplete urine composition should always be supplemented with data for the other urinary components. Guidelines for extension of urine composition were suggested. A requisite condition for formation of solid calcium oxalate in urine is the presence of active heterogeneous nuclei. Supersaturation of urine with respect to calcium oxalates per se cannot be regarded as a diagnostic measure of the risk of calcium oxalate stone formation. Graphical abstract Open image in new window COM formation through heterogenous nucleation on hydroxyapatite

Název v anglickém jazyce

Speciation and supersaturation of urine

Popis výsledku anglicky

Thermodynamic equilibria in urine at 37 oC showed that the inorganic urinary constituents, citrate and oxalate are present as 76 different species. Complexes formed by uric acid and various organic compounds, such as creatinine, proteins, hormones and metabolites, for which the relevant thermodynamic data are not available in the library of the computer program MINTEQA2 Version 3 were not considered. The actual thermodynamic supersaturation of urine with respect to calcium oxalate monohydrate and dihydrate was calculated. The effects of varying composition of urine at the same pH and the violation of the condition of electroneutrality on the calculated supersaturation were shown. The supersaturation of urine should never be computed from incomplete data of urine composition. Incomplete urine composition should always be supplemented with data for the other urinary components. Guidelines for extension of urine composition were suggested. A requisite condition for formation of solid calcium oxalate in urine is the presence of active heterogeneous nuclei. Supersaturation of urine with respect to calcium oxalates per se cannot be regarded as a diagnostic measure of the risk of calcium oxalate stone formation. Graphical abstract Open image in new window COM formation through heterogenous nucleation on hydroxyapatite

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte fur Chemie

ISSN

0026-9247

e-ISSN

—

Svazek periodika

2018

Číslo periodika v rámci svazku

149

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

7

Strana od-do

333-339

Kód UT WoS článku

000425536700015

EID výsledku v databázi Scopus

—