A panel of serum and urinary biomarkers helps to differentiate biopsy findings in patients with anca-associated vasculitis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13520%2F19%3A43895360" target="_blank" >RIV/44555601:13520/19:43895360 - isvavai.cz</a>

Výsledek na webu

<a href="https://academic.oup.com/rheumatology/article/58/Supplement_2/kez057.015/5422013" target="_blank" >https://academic.oup.com/rheumatology/article/58/Supplement_2/kez057.015/5422013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rheumatology/kez057.015" target="_blank" >10.1093/rheumatology/kez057.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A panel of serum and urinary biomarkers helps to differentiate biopsy findings in patients with anca-associated vasculitis

Popis výsledku v původním jazyce

Renal biopsy is considered a golden standard to diagnose vasculitis and assess disease activity/chronicity stage in patients with renal involvement in ANCA-associated vasculitis (AAV). The aim of this study was to assess the potential value of a biomarker panel for a non-invasive assessment of renal disease in AAV. The cohort consisted of 48 patients with AAV (M/F 29/19, median age years [range 28-81], PR3-ANCA/MPO-ANCA/double PR3- and MPO-ANCA 22/24/2) sampled at the time of their renal biopsy and 10 healthy controls. We measured PRO-C6 (formation of collagen type VI), DKK-3 (Dickkopf-related protein 3), C3M (degradation of collagen type III), soluble CD163 and EGF (epidermal growth factor) in paired serum and urine samples using ELISA method along with routine measurements of creatinine. Urinary markers were all normalized to urinary creatinine. Kidney biopsies were evaluated with a scoring system for AAV and interstitial fibrosis was quantified according to the Banff schema: grade 0: fibrosis less than 5%, grade 1: mild fibrosis (6-25%); grade 2: moderate fibrosis (26-50%) and grade 3: severe fibrosis (more than 50%).

Název v anglickém jazyce

A panel of serum and urinary biomarkers helps to differentiate biopsy findings in patients with anca-associated vasculitis

Popis výsledku anglicky

Renal biopsy is considered a golden standard to diagnose vasculitis and assess disease activity/chronicity stage in patients with renal involvement in ANCA-associated vasculitis (AAV). The aim of this study was to assess the potential value of a biomarker panel for a non-invasive assessment of renal disease in AAV. The cohort consisted of 48 patients with AAV (M/F 29/19, median age years [range 28-81], PR3-ANCA/MPO-ANCA/double PR3- and MPO-ANCA 22/24/2) sampled at the time of their renal biopsy and 10 healthy controls. We measured PRO-C6 (formation of collagen type VI), DKK-3 (Dickkopf-related protein 3), C3M (degradation of collagen type III), soluble CD163 and EGF (epidermal growth factor) in paired serum and urine samples using ELISA method along with routine measurements of creatinine. Urinary markers were all normalized to urinary creatinine. Kidney biopsies were evaluated with a scoring system for AAV and interstitial fibrosis was quantified according to the Banff schema: grade 0: fibrosis less than 5%, grade 1: mild fibrosis (6-25%); grade 2: moderate fibrosis (26-50%) and grade 3: severe fibrosis (more than 50%).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Rheumatology

ISSN

1462-0324

e-ISSN

—

Svazek periodika

2019

Číslo periodika v rámci svazku

58

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

7

Kód UT WoS článku

000478085100016

EID výsledku v databázi Scopus

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