Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46504711%3A_____%2F14%3A%230000425" target="_blank" >RIV/46504711:_____/14:#0000425 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles

Popis výsledku v původním jazyce

Complex magnetic oxides as core materials are interesting because their magnetic properties can be regulated by various ways very well. These magnetic nanoparticles can be interesting for application in biomedicine as a contrast agent for magnetic resonance imaging or as a colloidal mediator for destruction of cancer cells by magnetic fluid hyperthermia. Magnetic nanoparticles of manganite La0.75Sr0.25MnO3 were synthesized by sol - gel method. Prepared magnetic cores had to be converted into a stable and non toxic suspension to allow their administration either by intratumoural or intravenous way. For this purpose coating by silica shell was chosen, which provides stabilization by electrostatic repulsion. Silica shell was formed by polycondensation reactions of tetraethoxysilane hydrolytic products. Thickness of silica shell can significantly influence magnetic cores toxicity and quality of the suspension.

Název v anglickém jazyce

Influence of Silica Shell on Toxicity of Manganese Perovskite Magnetic Nanoparticles

Popis výsledku anglicky

Complex magnetic oxides as core materials are interesting because their magnetic properties can be regulated by various ways very well. These magnetic nanoparticles can be interesting for application in biomedicine as a contrast agent for magnetic resonance imaging or as a colloidal mediator for destruction of cancer cells by magnetic fluid hyperthermia. Magnetic nanoparticles of manganite La0.75Sr0.25MnO3 were synthesized by sol - gel method. Prepared magnetic cores had to be converted into a stable and non toxic suspension to allow their administration either by intratumoural or intravenous way. For this purpose coating by silica shell was chosen, which provides stabilization by electrostatic repulsion. Silica shell was formed by polycondensation reactions of tetraethoxysilane hydrolytic products. Thickness of silica shell can significantly influence magnetic cores toxicity and quality of the suspension.

Druh

D - Stať ve sborníku

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/FR-TI3%2F521" target="_blank" >FR-TI3/521: Technologie přípravy nových magnetických nanočástic pro diagnostiku a terapii v onkologii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ICNFA´14 Proceedings

ISBN

978-1-927877-10-4

ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

"129-1 – 129-2"

Název nakladatele

The International Academy of Science, Engineering and Technology

Místo vydání

Ottawa, Ontario, Kanada

Místo konání akce

Praha

Datum konání akce

11. 8. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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