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DRAWING FIBROUS SCAFFOLDS WITH PRECISE STRUCTURE FOR TISSUE ENGINEERING

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F14%3A00003522" target="_blank" >RIV/46747885:24210/14:00003522 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/46747885:24410/14:00003522

  • Výsledek na webu

    <a href="http://www.nanocon.eu/files/uploads/01/NANOCON" target="_blank" >http://www.nanocon.eu/files/uploads/01/NANOCON</a>

  • DOI - Digital Object Identifier

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    DRAWING FIBROUS SCAFFOLDS WITH PRECISE STRUCTURE FOR TISSUE ENGINEERING

  • Popis výsledku v původním jazyce

    This work is focused on evaluation of scaffolds made by drawing technique for the cell adhesion, viability and proliferation. With drawing we are able to produce very precise fibres with specified orientation from different polymers (PCL, PVA, PVB and others). This characteristic could be an advantage in tissues with ordered pattern. In the primary study the handmade fibres were tested for the cell growth and the results showed the potential of the cells to overgrow the gaps between the fibres. On account of these results further tests were necessary to be done with the precise machine-made fibrous scaffolds. The machine-made fibres are thinner, the gaps between the fibres are smaller and the whole structure is denser. In this study we focused on a planar scaffolds with fibres ordered either in one, in two or in three directions. Mice fibroblasts (3T3 Swiss Albino) were used for the in vitro experiment. The scaffolds were tested at day 1, 3, 7, 14, 21 and 28 after cell seeding. MTT assay, fluorescent microscopy and SEM analysis were used for the evaluation of cell adhesion, viability and proliferation. The results from microscopy analysis as well as from the MTT assay show, that the machine-made scaffolds are capable of supporting cellular attachment and proliferation during our in vitro tests. The scaffolds with crossed fibres show better results compared to fibres ordered in one direction. Nevertheless the one-direction fibres have a great potential in many tissue engineering applications, e.g. for muscles or neural tissue..

  • Název v anglickém jazyce

    DRAWING FIBROUS SCAFFOLDS WITH PRECISE STRUCTURE FOR TISSUE ENGINEERING

  • Popis výsledku anglicky

    This work is focused on evaluation of scaffolds made by drawing technique for the cell adhesion, viability and proliferation. With drawing we are able to produce very precise fibres with specified orientation from different polymers (PCL, PVA, PVB and others). This characteristic could be an advantage in tissues with ordered pattern. In the primary study the handmade fibres were tested for the cell growth and the results showed the potential of the cells to overgrow the gaps between the fibres. On account of these results further tests were necessary to be done with the precise machine-made fibrous scaffolds. The machine-made fibres are thinner, the gaps between the fibres are smaller and the whole structure is denser. In this study we focused on a planar scaffolds with fibres ordered either in one, in two or in three directions. Mice fibroblasts (3T3 Swiss Albino) were used for the in vitro experiment. The scaffolds were tested at day 1, 3, 7, 14, 21 and 28 after cell seeding. MTT assay, fluorescent microscopy and SEM analysis were used for the evaluation of cell adhesion, viability and proliferation. The results from microscopy analysis as well as from the MTT assay show, that the machine-made scaffolds are capable of supporting cellular attachment and proliferation during our in vitro tests. The scaffolds with crossed fibres show better results compared to fibres ordered in one direction. Nevertheless the one-direction fibres have a great potential in many tissue engineering applications, e.g. for muscles or neural tissue..

Klasifikace

  • Druh

    D - Stať ve sborníku

  • CEP obor

    FP - Ostatní lékařské obory

  • OECD FORD obor

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/ED3.1.00%2F14.0306" target="_blank" >ED3.1.00/14.0306: Inovativní výrobky a environmentální technologie</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2014

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název statě ve sborníku

    NANOCON 2014 - Conference Proceedings, 6th International Conference

  • ISBN

    978-80-87294-53-6

  • ISSN

  • e-ISSN

  • Počet stran výsledku

    6

  • Strana od-do

    508-513

  • Název nakladatele

    TANGER LTD, OSTRAVA

  • Místo vydání

    Ostrava, CZECH REPUBLIC

  • Místo konání akce

    Brno, CZECH REPUBLIC

  • Datum konání akce

    1. 1. 2014

  • Typ akce podle státní příslušnosti

    WRD - Celosvětová akce

  • Kód UT WoS článku

    000350636300087