Long-term comparative study of the stability of nanofibrous materials from biodegradable polycaprolactone for skin wound dressing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F24%3A00011770" target="_blank" >RIV/46747885:24210/24:00011770 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24410/24:00011770 RIV/46747885:24510/24:00011770 RIV/46747885:24620/24:00011770

Výsledek na webu

<a href="https://doi.org/10.37904/nanocon.2023.4792" target="_blank" >https://doi.org/10.37904/nanocon.2023.4792</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2023.4792" target="_blank" >10.37904/nanocon.2023.4792</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term comparative study of the stability of nanofibrous materials from biodegradable polycaprolactone for skin wound dressing

Popis výsledku v původním jazyce

This study deals with a long-term stability study of biodegradable polycaprolactone (PCL) nanofibrous dressings for skin applications, an important parameter for the storage of materials prior to actual application. Nanofibrous materials generally have suitable properties for regenerative medicine and tissue engineering, such as high porosity with small pore size, high areal density of fibers, large specific surface area, and these materials are able to mimic natural skin extracellular matrix with their fibrous structure. These properties allow nanofibrous dressings to provide the required protection to damaged tissues while promoting the wound-healing process. However, the issue of their long-term stability and degradation behaviour is still under investigation. The aim of this study was to observe and compare the long-term stability of electrospun PCL nanofibrous dressings exposed to different storage conditions. The study focused on the effect of nanofibrous material parameters, which included the surface weight; the solvent system used during the preparation of the polymeric spinning solutions and last but not least, the effect of ethylene oxide sterilization on the stability of the nanofibrous planar dressing over a period of 6-12 months.

Název v anglickém jazyce

Long-term comparative study of the stability of nanofibrous materials from biodegradable polycaprolactone for skin wound dressing

Popis výsledku anglicky

This study deals with a long-term stability study of biodegradable polycaprolactone (PCL) nanofibrous dressings for skin applications, an important parameter for the storage of materials prior to actual application. Nanofibrous materials generally have suitable properties for regenerative medicine and tissue engineering, such as high porosity with small pore size, high areal density of fibers, large specific surface area, and these materials are able to mimic natural skin extracellular matrix with their fibrous structure. These properties allow nanofibrous dressings to provide the required protection to damaged tissues while promoting the wound-healing process. However, the issue of their long-term stability and degradation behaviour is still under investigation. The aim of this study was to observe and compare the long-term stability of electrospun PCL nanofibrous dressings exposed to different storage conditions. The study focused on the effect of nanofibrous material parameters, which included the surface weight; the solvent system used during the preparation of the polymeric spinning solutions and last but not least, the effect of ethylene oxide sterilization on the stability of the nanofibrous planar dressing over a period of 6-12 months.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

CONFERENCE PROCEEDINGS - NANOCON 2023

ISBN

978-80-88365-13-6

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

10

Strana od-do

303-312

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

1. 1. 2023

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

001234125400049