Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in H-1/P-31 magnetic resonance imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F22%3A00010973" target="_blank" >RIV/46747885:24220/22:00010973 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-022-06125-7" target="_blank" >https://www.nature.com/articles/s41598-022-06125-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-022-06125-7" target="_blank" >10.1038/s41598-022-06125-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in H-1/P-31 magnetic resonance imaging

Popis výsledku v původním jazyce

We present the MR properties of a novel bio-responsive phosphorus probe doped with iron for dual proton and phosphorus magnetic resonance imaging (H-1/P-31-MRI), which provide simultaneously complementary information. The probes consist of non-toxic biodegradable calcium phytate (CaIP6) nanoparticles doped with different amounts of cleavable paramagnetic Fe3 ions. Phosphorus atoms in the phytate structure delivered an efficient P-31-MR signal, with iron ions altering MR contrast for both H-1 and P-31-MR. The coordinated paramagnetic Fe3 ions broadened the P-31-MR signal spectral line due to the short T-2 relaxation time, resulting in more hypointense signal. However, when Fe3 was decomplexed from the probe, relaxation times were prolonged. As a result of iron release, intensity of H-1-MR, as well as the P-31-MR signal increase. These H-1 and P-31-MR dual signals triggered by iron decomplexation may have been attributable to biochemical changes in the environment with strong iron chelators, such as bacterial siderophore (deferoxamine). Analysing MR signal alternations as a proof-of-principle on a phantom at a 4.7 T magnetic field, we found that iron presence influenced H-1 and P-31 signals and signal recovery via iron chelation using deferoxamine.

Název v anglickém jazyce

Iron-doped calcium phytate nanoparticles as a bio-responsive contrast agent in H-1/P-31 magnetic resonance imaging

Popis výsledku anglicky

We present the MR properties of a novel bio-responsive phosphorus probe doped with iron for dual proton and phosphorus magnetic resonance imaging (H-1/P-31-MRI), which provide simultaneously complementary information. The probes consist of non-toxic biodegradable calcium phytate (CaIP6) nanoparticles doped with different amounts of cleavable paramagnetic Fe3 ions. Phosphorus atoms in the phytate structure delivered an efficient P-31-MR signal, with iron ions altering MR contrast for both H-1 and P-31-MR. The coordinated paramagnetic Fe3 ions broadened the P-31-MR signal spectral line due to the short T-2 relaxation time, resulting in more hypointense signal. However, when Fe3 was decomplexed from the probe, relaxation times were prolonged. As a result of iron release, intensity of H-1-MR, as well as the P-31-MR signal increase. These H-1 and P-31-MR dual signals triggered by iron decomplexation may have been attributable to biochemical changes in the environment with strong iron chelators, such as bacterial siderophore (deferoxamine). Analysing MR signal alternations as a proof-of-principle on a phantom at a 4.7 T magnetic field, we found that iron presence influenced H-1 and P-31 signals and signal recovery via iron chelation using deferoxamine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

000756832600024

EID výsledku v databázi Scopus

2-s2.0-85124286306