INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00003864" target="_blank" >RIV/46747885:24410/16:00003864 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nanocon.eu/cz/" target="_blank" >http://www.nanocon.eu/cz/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS

Popis výsledku v původním jazyce

Nitric Oxide (NO) is a very promising molecule suitable for applications in cardiovascular system. NO has many beneficial effects such as anti-thrombogenic and anti-inflammatory properties together with endothelial cell support. Presented work was focused on functionalization of electrospun biodegradable materials by nitric oxide donors for further usage as vascular grafts. Firstly, the optimization of biodegradable nanofibrous layers was carried out. Fibrous sheets were produced from the aliphatic polyester polycaprolactone (PCL) that was blended with nitric oxide donor S-nitrosoacetyl N-penicillamine (SNAPs) in various concentrations of 0.2 wt % and 0.4 wt%. Subsequently, prepared layers with and without NO donors were tested in vitro using endothelial cells and its effect was compared. Nitric oxide release from functionalized layers was detected by colorimetric Griess assay after 1, 2 and 3 days of incubation. Moreover, sterilization methods and their impact for NO release was monitored.

Název v anglickém jazyce

INCORPORATION NITRIC OXIDE DONORS INTO FIBROUS MATERIAL INTENDED FOR VASCULAR GRAFTS

Popis výsledku anglicky

Nitric Oxide (NO) is a very promising molecule suitable for applications in cardiovascular system. NO has many beneficial effects such as anti-thrombogenic and anti-inflammatory properties together with endothelial cell support. Presented work was focused on functionalization of electrospun biodegradable materials by nitric oxide donors for further usage as vascular grafts. Firstly, the optimization of biodegradable nanofibrous layers was carried out. Fibrous sheets were produced from the aliphatic polyester polycaprolactone (PCL) that was blended with nitric oxide donor S-nitrosoacetyl N-penicillamine (SNAPs) in various concentrations of 0.2 wt % and 0.4 wt%. Subsequently, prepared layers with and without NO donors were tested in vitro using endothelial cells and its effect was compared. Nitric oxide release from functionalized layers was detected by colorimetric Griess assay after 1, 2 and 3 days of incubation. Moreover, sterilization methods and their impact for NO release was monitored.

Druh

D - Stať ve sborníku

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NV15-29241A" target="_blank" >NV15-29241A: Nanovlákenná biodegradabilní maloprůměrová cévní náhrada</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

ISBN

978-80-87294-71-0

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

424-428

Název nakladatele

Tanger Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

1. 1. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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