Degradation behavior of electrospun resorbable polyester nano/micro fibrous materials

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F17%3A00004236" target="_blank" >RIV/46747885:24410/17:00004236 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/17:00004236

Výsledek na webu

<a href="https://www.elsevier.com/events/conferences/frontiers-in-polymer-science" target="_blank" >https://www.elsevier.com/events/conferences/frontiers-in-polymer-science</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Degradation behavior of electrospun resorbable polyester nano/micro fibrous materials

Popis výsledku v původním jazyce

Introduction: Electrospun fibers provide high surface-to-volume ratio and high porosity which is promising structure of scaffolds for the tissue engineering. Degradation behavior of the material becomes one of the crucial factors, because it significantly affect tissue regeneration process. In presented work we tested degradation behavior of polyester electrospun materials with various morphologies. Methods: polyesters polycaprolactone (PCL, molecular weights 45,000 and 80,000) and copolymer of polylactide and polycaprolactone (PLCL, molecular weight 80,000) were electrospun by needleless electrospinning method. Fibrous structures of fiber diameter from nanometers to several micrometers were prepared. Degradation of prepared materials was accelerated using enzymes for catalysis (Proteinase K and Lipase). Samples were further analyzed for the weight loss, morphology (SEM), and molecular weight loss (GPC). Results: The increasing fiber diameter as well as increasing molecular weight of used polymer has the negative effect on the degradation rate (speed). For all tested materials, there was not observed any change in molar mass distribution during degradation. The morphology of tested materials changes significantly during degradation as well as crystallinity, which increased in all samples. Discussion: During degradation of all polyester fibrous materials we observed fiber melting, recrystallization and fiber breaking, whereas there is no change in molar mass distribution in remaining fibrous material during degradation which is characteristic for bulk errosion (Dong et al., 2009). Obtained data clearly define the mechanism of degradation of tested fibrous materials as the surface erosion mechanism.

Název v anglickém jazyce

Degradation behavior of electrospun resorbable polyester nano/micro fibrous materials

Popis výsledku anglicky

Introduction: Electrospun fibers provide high surface-to-volume ratio and high porosity which is promising structure of scaffolds for the tissue engineering. Degradation behavior of the material becomes one of the crucial factors, because it significantly affect tissue regeneration process. In presented work we tested degradation behavior of polyester electrospun materials with various morphologies. Methods: polyesters polycaprolactone (PCL, molecular weights 45,000 and 80,000) and copolymer of polylactide and polycaprolactone (PLCL, molecular weight 80,000) were electrospun by needleless electrospinning method. Fibrous structures of fiber diameter from nanometers to several micrometers were prepared. Degradation of prepared materials was accelerated using enzymes for catalysis (Proteinase K and Lipase). Samples were further analyzed for the weight loss, morphology (SEM), and molecular weight loss (GPC). Results: The increasing fiber diameter as well as increasing molecular weight of used polymer has the negative effect on the degradation rate (speed). For all tested materials, there was not observed any change in molar mass distribution during degradation. The morphology of tested materials changes significantly during degradation as well as crystallinity, which increased in all samples. Discussion: During degradation of all polyester fibrous materials we observed fiber melting, recrystallization and fiber breaking, whereas there is no change in molar mass distribution in remaining fibrous material during degradation which is characteristic for bulk errosion (Dong et al., 2009). Obtained data clearly define the mechanism of degradation of tested fibrous materials as the surface erosion mechanism.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů