Protein adsorption on biodegradable mikro/nanofibres materials for tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F24%3A00011662" target="_blank" >RIV/46747885:24410/24:00011662 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24510/24:00011662 RIV/46747885:24620/24:00011662

Výsledek na webu

<a href="https://doi.org/10.37904/nanocon.2023.4795" target="_blank" >https://doi.org/10.37904/nanocon.2023.4795</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2023.4795" target="_blank" >10.37904/nanocon.2023.4795</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Protein adsorption on biodegradable mikro/nanofibres materials for tissue engineering

Popis výsledku v původním jazyce

Due to their specific properties, nanofibrous materials are increasingly used in regenerative medicine and tissue engineering. Nanofibrous materials can be used as tissue scaffolds for injured (damaged) tissue. The main factor for tissue scaffolds is their biocompatibility. One of the main factors influencing the organism‘s physiological response is the interaction of the material with proteins. Proteins adsorbed on the material‘s surface give the tissue scaffolds a „biological identity”. Cells in the organism subsequently interact with proteins adsorbed on the material‘s surface and determine the entire organism‘s response to the implanted material. This work deals with the influence of the morphology and chemical composition of polyester nanofibrous materials on the adsorption of proteins. The materials produced by electrospinning (DC spinning) were characterised from the point of view of morphology and wettability. Then, the adsorption of weakly and strongly bound proteins on the fibre surface was evaluated. Cell adhesion and proliferation on the tested materials were also observed. The results of protein adsorption were compared with the results of cell adhesion and proliferation to determine the effect of the amount of adsorbed proteins on the interaction of cells with the tested materials.

Název v anglickém jazyce

Protein adsorption on biodegradable mikro/nanofibres materials for tissue engineering

Popis výsledku anglicky

Due to their specific properties, nanofibrous materials are increasingly used in regenerative medicine and tissue engineering. Nanofibrous materials can be used as tissue scaffolds for injured (damaged) tissue. The main factor for tissue scaffolds is their biocompatibility. One of the main factors influencing the organism‘s physiological response is the interaction of the material with proteins. Proteins adsorbed on the material‘s surface give the tissue scaffolds a „biological identity”. Cells in the organism subsequently interact with proteins adsorbed on the material‘s surface and determine the entire organism‘s response to the implanted material. This work deals with the influence of the morphology and chemical composition of polyester nanofibrous materials on the adsorption of proteins. The materials produced by electrospinning (DC spinning) were characterised from the point of view of morphology and wettability. Then, the adsorption of weakly and strongly bound proteins on the fibre surface was evaluated. Cell adhesion and proliferation on the tested materials were also observed. The results of protein adsorption were compared with the results of cell adhesion and proliferation to determine the effect of the amount of adsorbed proteins on the interaction of cells with the tested materials.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20500 - Materials engineering

Projekt

<a href="/cs/project/EH22_008%2F0004562" target="_blank" >EH22_008/0004562: Excelentní výzkum v regenerativní medicíně</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2023 - Conference Proceedings, 15th International Conference on Nanomaterials

ISBN

—

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

8

Strana od-do

290-297

Název nakladatele

Moravapress s.r.o.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

1. 1. 2023

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

001234125400047