PULLULAN-DOX/PVA-PDMS BIOPOLYMERIC CORE-SHELL NANOFIBERS POTENTIAL FOR DRUG DELIVERY SYSTEMS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F24%3A00012526" target="_blank" >RIV/46747885:24410/24:00012526 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.7216/teksmuh.1496634" target="_blank" >https://doi.org/10.7216/teksmuh.1496634</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7216/teksmuh.1496634" target="_blank" >10.7216/teksmuh.1496634</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PULLULAN-DOX/PVA-PDMS BIOPOLYMERIC CORE-SHELL NANOFIBERS POTENTIAL FOR DRUG DELIVERY SYSTEMS

Popis výsledku v původním jazyce

In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochloride (DOX) into Pullulan and integrating the core into a polyvinyl alcohol (PVA) and Polydimethoxysilane (PDMS) composite matrix. The incorporation of DOX into the pullulan solution was carried out to take advantage of Pullulan‘s biocompatibility, biodegradability and hydrophilic nature. The hydrophilic nature of PVA can result in rapid drug release, while the hydrophobic nature of PDMS allows for slower drug release. The use of PVA-PDMS polymers together in the shell offers an initial rapid release followed by a prolonged and controlled drug release. This combination is superior to PVA or PDMS in terms of safety, mechanical strength, flexibility, controlled drug release and structural stability. This innovative composite system was designed to optimise DOX‘s controlled release to increase its therapeutic efficacy and reduce systemic toxicity. The kinetics of the drug release was characterised by an initial burst release followed by a sustained release phase, allowing controlled and prolonged release of the chemotherapeutic agent. Our results indicate that the pullulan/PVA-PDMS composite is a promising candidate for practical drug delivery applications, especially in cancer therapy.

Název v anglickém jazyce

PULLULAN-DOX/PVA-PDMS BIOPOLYMERIC CORE-SHELL NANOFIBERS POTENTIAL FOR DRUG DELIVERY SYSTEMS

Popis výsledku anglicky

In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochloride (DOX) into Pullulan and integrating the core into a polyvinyl alcohol (PVA) and Polydimethoxysilane (PDMS) composite matrix. The incorporation of DOX into the pullulan solution was carried out to take advantage of Pullulan‘s biocompatibility, biodegradability and hydrophilic nature. The hydrophilic nature of PVA can result in rapid drug release, while the hydrophobic nature of PDMS allows for slower drug release. The use of PVA-PDMS polymers together in the shell offers an initial rapid release followed by a prolonged and controlled drug release. This combination is superior to PVA or PDMS in terms of safety, mechanical strength, flexibility, controlled drug release and structural stability. This innovative composite system was designed to optimise DOX‘s controlled release to increase its therapeutic efficacy and reduce systemic toxicity. The kinetics of the drug release was characterised by an initial burst release followed by a sustained release phase, allowing controlled and prolonged release of the chemotherapeutic agent. Our results indicate that the pullulan/PVA-PDMS composite is a promising candidate for practical drug delivery applications, especially in cancer therapy.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tekstil ve Muhendis

ISSN

1300-7599

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

135

Stát vydavatele periodika

TR - Turecká republika

Počet stran výsledku

12

Strana od-do

110-120

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85207036820