Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F26%3A00013747" target="_blank" >RIV/46747885:24410/26:00013747 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/adhm.202502971" target="_blank" >https://doi.org/10.1002/adhm.202502971</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adhm.202502971" target="_blank" >10.1002/adhm.202502971</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing

Popis výsledku v původním jazyce

The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 degrees C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound healing ability in rats. The results show that the hydrogel has a large number of intermolecular and intramolecular hydrogen bonds and a porous 3D network structure. The swelling ratio is 358.86 +/- 23.56% and the degradation ratio is 86.02 +/- 2.82% at 21 days. It also has excellent antibacterial properties against Escherichia coli and a much faster wound recovery ability. Therefore, a chitosan hydrogel with excellent physical properties is formulated in this study and has great potential as a smart all-in-one wound dressing for accelerating wound healing.

Název v anglickém jazyce

Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing

Popis výsledku anglicky

The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 degrees C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound healing ability in rats. The results show that the hydrogel has a large number of intermolecular and intramolecular hydrogen bonds and a porous 3D network structure. The swelling ratio is 358.86 +/- 23.56% and the degradation ratio is 86.02 +/- 2.82% at 21 days. It also has excellent antibacterial properties against Escherichia coli and a much faster wound recovery ability. Therefore, a chitosan hydrogel with excellent physical properties is formulated in this study and has great potential as a smart all-in-one wound dressing for accelerating wound healing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20901 - Industrial biotechnology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2026

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ADVANCED HEALTHCARE MATERIALS>

ISSN

2192-2640

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

—

Kód UT WoS článku

001587800500001

EID výsledku v databázi Scopus

2-s2.0-105018323056