Initial screening of silica nanofibres as drug delivery system for antibiotics in wound healing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F22%3A00011737" target="_blank" >RIV/46747885:24510/22:00011737 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/22:00011737

Výsledek na webu

<a href="https://www.confer.cz/nanocon/2022/4611-initial-screening-of-silica-nanofibres-as-drug-delivery-system-for-antibiotics-in-wound-healing" target="_blank" >https://www.confer.cz/nanocon/2022/4611-initial-screening-of-silica-nanofibres-as-drug-delivery-system-for-antibiotics-in-wound-healing</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2022.4611" target="_blank" >10.37904/nanocon.2022.4611</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Initial screening of silica nanofibres as drug delivery system for antibiotics in wound healing

Popis výsledku v původním jazyce

Over the last decade, drug delivery systems for wound management have undergone a significant evolution as novel nano-based dosage forms and wound dressing pads for active wound management have been developed. Significance of these materials is based on the increasing demand for active wound dressing able to battle infection and inflammation in contaminated and slow-to-heal wounds. Nanofibres represent nanomaterials able to act simultaneously as wound dressing, protecting the wound, and drug delivery system for in situ drug release. Bioavailability of the drug and its release kinetics strongly depend on the drug‘s nature, nanofibrous matrix characteristics and mechanism of drug incorporation. In bacterial infection treatment, fast reaching of minimal inhibitory concentration (MIC) is crucial and can be achieved by mediated surface drug adsorption. In this work, we explored interactions of electrospun silica nanofibres with five model antibiotics from the tetracycline family in order to evaluate robustness of this novel nanofibrous drug delivery system. Drug-functionalized nanofibres were studied in terms of morphology and total drug content. Antibacterial activity against bacteria E. coli was tested in vitro. Overcoming the MIC value was achieved for all tested antibiotics. Biocompatibility was tested and confirmed on human dermal fibroblasts in vitro. Presence of all tested antibiotics led to increased cellular metabolic activity. Based on these results, we assumed that silica nanofibres represent a robust system able to bind and release variety of tetracycline antibiotics for contaminated wound management.

Název v anglickém jazyce

Initial screening of silica nanofibres as drug delivery system for antibiotics in wound healing

Popis výsledku anglicky

Over the last decade, drug delivery systems for wound management have undergone a significant evolution as novel nano-based dosage forms and wound dressing pads for active wound management have been developed. Significance of these materials is based on the increasing demand for active wound dressing able to battle infection and inflammation in contaminated and slow-to-heal wounds. Nanofibres represent nanomaterials able to act simultaneously as wound dressing, protecting the wound, and drug delivery system for in situ drug release. Bioavailability of the drug and its release kinetics strongly depend on the drug‘s nature, nanofibrous matrix characteristics and mechanism of drug incorporation. In bacterial infection treatment, fast reaching of minimal inhibitory concentration (MIC) is crucial and can be achieved by mediated surface drug adsorption. In this work, we explored interactions of electrospun silica nanofibres with five model antibiotics from the tetracycline family in order to evaluate robustness of this novel nanofibrous drug delivery system. Drug-functionalized nanofibres were studied in terms of morphology and total drug content. Antibacterial activity against bacteria E. coli was tested in vitro. Overcoming the MIC value was achieved for all tested antibiotics. Biocompatibility was tested and confirmed on human dermal fibroblasts in vitro. Presence of all tested antibiotics led to increased cellular metabolic activity. Based on these results, we assumed that silica nanofibres represent a robust system able to bind and release variety of tetracycline antibiotics for contaminated wound management.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30401 - Health-related biotechnology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2022 - Conference Proceedings, 14th International Conference on Nanomaterials

ISBN

978-80-88365-09-9

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

6

Strana od-do

223-228

Název nakladatele

Tanger Ltd

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

1. 1. 2022

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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