Water-soluble fluorinated copolymers as highly sensitive 19F MRI tracers: From structure optimization to multimodal tumor imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24530%2F25%3A00013297" target="_blank" >RIV/46747885:24530/25:00013297 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2590006425000201?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2590006425000201?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mtbio.2025.101462" target="_blank" >10.1016/j.mtbio.2025.101462</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Water-soluble fluorinated copolymers as highly sensitive 19F MRI tracers: From structure optimization to multimodal tumor imaging

Popis výsledku v původním jazyce

Fluorine magnetic resonance imaging (19F MRI) using polymer tracers overcomes limitations of conventional proton MRI by offering enhanced specificity. However, the lack of systematic comparisons among fluorinated polymers has hindered rational tracer design. In this study, we synthesized an extensive library of watersoluble fluorinated copolymers by varying ratios of hydrophilic and fluorinated monomers and evaluated their 19 F MRI properties to identify key structure-property relationships. Optimizing the hydrophilicity of the non-fluorinated comonomer increased fluorine content without compromising water solubility, thereby enhancing the MRI signal. Factors such as chemical structure, molecular interactions, and magnetic relaxation times also significantly influenced tracer performance. The optimized copolymer, poly((N-(2,2,2-trifluoroethyl)acrylamide)60-stat-(N-(2-hydroxyethyl)acrylamide)40), exhibited unprecedented 19 F MRI sensitivity with detection limits below 1 mg mL-1, the highest reported to date. We demonstrated the tracer‘s potential through successful in vivo 19 F MRI visualization of solid tumors in mouse models, highlighting its promise for advanced biomedical imaging applications.

Název v anglickém jazyce

Water-soluble fluorinated copolymers as highly sensitive 19F MRI tracers: From structure optimization to multimodal tumor imaging

Popis výsledku anglicky

Fluorine magnetic resonance imaging (19F MRI) using polymer tracers overcomes limitations of conventional proton MRI by offering enhanced specificity. However, the lack of systematic comparisons among fluorinated polymers has hindered rational tracer design. In this study, we synthesized an extensive library of watersoluble fluorinated copolymers by varying ratios of hydrophilic and fluorinated monomers and evaluated their 19 F MRI properties to identify key structure-property relationships. Optimizing the hydrophilicity of the non-fluorinated comonomer increased fluorine content without compromising water solubility, thereby enhancing the MRI signal. Factors such as chemical structure, molecular interactions, and magnetic relaxation times also significantly influenced tracer performance. The optimized copolymer, poly((N-(2,2,2-trifluoroethyl)acrylamide)60-stat-(N-(2-hydroxyethyl)acrylamide)40), exhibited unprecedented 19 F MRI sensitivity with detection limits below 1 mg mL-1, the highest reported to date. We demonstrated the tracer‘s potential through successful in vivo 19 F MRI visualization of solid tumors in mouse models, highlighting its promise for advanced biomedical imaging applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MATERIALS TODAY BIO

ISSN

2590-0064

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

101462

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

001399569000001

EID výsledku v databázi Scopus

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