Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47122099%3A_____%2F25%3AN0000014" target="_blank" >RIV/47122099:_____/25:N0000014 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/25:00001575 RIV/00216208:11110/25:10507257 RIV/00216208:11130/25:10507257 RIV/00064203:_____/25:10507257

Výsledek na webu

<a href="https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1725486/full" target="_blank" >https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2025.1725486/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnagi.2025.1725486" target="_blank" >10.3389/fnagi.2025.1725486</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Popis výsledku v původním jazyce

Objectives To evaluate cognitive and mood changes 3 months after shunting for idiopathic normal-pressure hydrocephalus (iNPH), and compare postoperative outcomes with matched healthy controls across cognitive domains. Methods Thirty-three iNPH patients underwent neuropsychological testing preoperatively and at 3 months; 71 age-, sex-, and education-matched controls were assessed once. Tests were grouped into six cognitive domains.Results Shunting yielded significant gains in Verbal Memory and Psychomotor Pace; Executive Functions improved selectively. Non-Verbal Memory, Language, and Visuospatial Abilities showed no postoperative change. Depressive symptoms decreased significantly. However, at 3 months patients still performed worse than controls on all tests (all p < 0.001). Conclusion Shunt surgery produces measurable yet domain-limited cognitive benefits in iNPH at 3 months, particularly in verbal learning and processing speed, alongside mood improvement. Performance remains below healthy norms, indicating partial recovery. Larger, prospective cohorts and longer follow-up are needed to determine durability, breadth of cognitive change, and predictors of response.

Název v anglickém jazyce

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Popis výsledku anglicky

Objectives To evaluate cognitive and mood changes 3 months after shunting for idiopathic normal-pressure hydrocephalus (iNPH), and compare postoperative outcomes with matched healthy controls across cognitive domains. Methods Thirty-three iNPH patients underwent neuropsychological testing preoperatively and at 3 months; 71 age-, sex-, and education-matched controls were assessed once. Tests were grouped into six cognitive domains.Results Shunting yielded significant gains in Verbal Memory and Psychomotor Pace; Executive Functions improved selectively. Non-Verbal Memory, Language, and Visuospatial Abilities showed no postoperative change. Depressive symptoms decreased significantly. However, at 3 months patients still performed worse than controls on all tests (all p < 0.001). Conclusion Shunt surgery produces measurable yet domain-limited cognitive benefits in iNPH at 3 months, particularly in verbal learning and processing speed, alongside mood improvement. Performance remains below healthy norms, indicating partial recovery. Larger, prospective cohorts and longer follow-up are needed to determine durability, breadth of cognitive change, and predictors of response.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

50100 - Psychology and cognitive sciences

Projekt

<a href="/cs/project/NU23-04-00551" target="_blank" >NU23-04-00551: Komplexní multidoménová diagnostická baterie pro NPH</a><br>

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FRONTIERS IN AGING NEUROSCIENCE

ISSN

1663-4365

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

12 December 2025

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

1725486

Kód UT WoS článku

001649461000001

EID výsledku v databázi Scopus

2-s2.0-105026792376