Bistability in self-activating genes regulated by non-coding RNAs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47813059%3A19240%2F14%3A%230005516" target="_blank" >RIV/47813059:19240/14:#0005516 - isvavai.cz</a>

Výsledek na webu

<a href="http://stacks.iop.org/1742-6596/574/i=1/a=012164" target="_blank" >http://stacks.iop.org/1742-6596/574/i=1/a=012164</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1742-6596/574/1/012164" target="_blank" >10.1088/1742-6596/574/1/012164</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bistability in self-activating genes regulated by non-coding RNAs

Popis výsledku v původním jazyce

Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is an important behaviour of genetic networks. Here, we propose and study an ODE model in order to show how non-coding RNA can produce bistability in a simple way. The model comprises a single gene with positive feedback that is repressed by non-coding RNA molecules. We show how the values of all the reaction rates involved in the model are able to control the transitions between the high and low states. This new model can be interesting to clarify the role of non-coding RNA molecules in genetic networks. As well, these results can be interesting in synthetic biology for developing new genetic memories and biomolecular devices based on non-coding RNAs.

Název v anglickém jazyce

Bistability in self-activating genes regulated by non-coding RNAs

Popis výsledku anglicky

Non-coding RNA molecules are able to regulate gene expression and play an essential role in cells. On the other hand, bistability is an important behaviour of genetic networks. Here, we propose and study an ODE model in order to show how non-coding RNA can produce bistability in a simple way. The model comprises a single gene with positive feedback that is repressed by non-coding RNA molecules. We show how the values of all the reaction rates involved in the model are able to control the transitions between the high and low states. This new model can be interesting to clarify the role of non-coding RNA molecules in genetic networks. As well, these results can be interesting in synthetic biology for developing new genetic memories and biomolecular devices based on non-coding RNAs.

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Journal of Physics: Conference Series

ISBN

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ISSN

1742-6588

e-ISSN

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Počet stran výsledku

4

Strana od-do

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Název nakladatele

Institute of Physics Publishing

Místo vydání

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Místo konání akce

Madrid, Spain

Datum konání akce

1. 1. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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