A Self‐Controlled and Self‐Healing Model of Bacterial Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47813059%3A19240%2F22%3AA0001001" target="_blank" >RIV/47813059:19240/22:A0001001 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2077-0375/12/7/678" target="_blank" >https://www.mdpi.com/2077-0375/12/7/678</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/membranes12070678" target="_blank" >10.3390/membranes12070678</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Self‐Controlled and Self‐Healing Model of Bacterial Cells

Popis výsledku v původním jazyce

A new kind of self‐assembly model, morphogenetic (M) systems, assembles spatial units into larger structures through local interactions of simpler components and enables discovery of new principles for cellular membrane assembly, development, and its interface function. The model is based on interactions among three kinds of constitutive objects such as tiles and protein‐like elements in discrete time and continuous 3D space. It was motivated by achieving a balance between three conflicting goals: biological, physical‐chemical, and computational realism. A recent example is a unified model of morphogenesis of a single biological cell, its membrane and cytoskeleton formation, and finally, its self‐reproduction. Here, a family of dynamic M systems (Mbac) is described with similar characteristics, modeling the process of bacterial cell formation and division that exhibits bacterial behaviors of living cells at the macro‐level (including cell growth that is self‐controlled and sensitive to the presence/absence of nutrients transported through membranes), as well as self‐healing properties. Remarkably, it consists of only 20 or so developmental rules. Furthermore, since the model exhibits membrane formation and septic mitosis, it affords more rigorous definitions of concepts such as injury and self‐healing that enable quantitative analyses of these kinds of properties. Mbac shows that self‐assembly and interactions of living organisms with their environments and membrane interfaces are critical for self‐healing, and that these properties can be defined and quantified more rigorously and precisely, despite their complexity.

Název v anglickém jazyce

A Self‐Controlled and Self‐Healing Model of Bacterial Cells

Popis výsledku anglicky

A new kind of self‐assembly model, morphogenetic (M) systems, assembles spatial units into larger structures through local interactions of simpler components and enables discovery of new principles for cellular membrane assembly, development, and its interface function. The model is based on interactions among three kinds of constitutive objects such as tiles and protein‐like elements in discrete time and continuous 3D space. It was motivated by achieving a balance between three conflicting goals: biological, physical‐chemical, and computational realism. A recent example is a unified model of morphogenesis of a single biological cell, its membrane and cytoskeleton formation, and finally, its self‐reproduction. Here, a family of dynamic M systems (Mbac) is described with similar characteristics, modeling the process of bacterial cell formation and division that exhibits bacterial behaviors of living cells at the macro‐level (including cell growth that is self‐controlled and sensitive to the presence/absence of nutrients transported through membranes), as well as self‐healing properties. Remarkably, it consists of only 20 or so developmental rules. Furthermore, since the model exhibits membrane formation and septic mitosis, it affords more rigorous definitions of concepts such as injury and self‐healing that enable quantitative analyses of these kinds of properties. Mbac shows that self‐assembly and interactions of living organisms with their environments and membrane interfaces are critical for self‐healing, and that these properties can be defined and quantified more rigorously and precisely, despite their complexity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Membranes

ISSN

2077-0375

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

1-16

Kód UT WoS článku

000833792100001

EID výsledku v databázi Scopus

2-s2.0-85133703268