From a Passive Conduit to Highly Dynamic Organ - What are the Roles of Uterine Tube Epithelium in Reproduction?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23310%2F22%3A43966632" target="_blank" >RIV/49777513:23310/22:43966632 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.biomed.cas.cz/physiolres/pdf/2022/71_S11.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2022/71_S11.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33549/physiolres.934954" target="_blank" >10.33549/physiolres.934954</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
From a Passive Conduit to Highly Dynamic Organ - What are the Roles of Uterine Tube Epithelium in Reproduction?
Popis výsledku v původním jazyce
It is well known that the mammalian uterine tube (UT) plays a crucial role in female fertility, where the most important events leading to successful fertilization and pre-implantation embryo development occur. The known functions of these small intraabdominal organs are: an uptake and transport of oocytes; storage, transportation, and capacitation of spermatozoa, and finally fertilization and transport of the fertilized ovum and early embryo through the isthmus towards the uterotubal junction. The success of all these events depends on the interaction between the uterine tube epithelium (UTE) and gametes/embryo. Besides that, contemporary research revealed that the tubal epithelium provides essential nutritional support and the most suitable environment for early embryo development. Moreover, recent discoveries in molecular biology help understand the role of the epithelium at the cellular and molecular levels, highlighting the factors involved in regulating the UT signaling, that affects different steps in the fertilization process. According to the latest research, the extracellular vesicles, as a major component of tubal secretion, mediate the interaction between gametes/embryo and epithelium. This review aims to provide up-to-date knowledge on various aspects concerning tubal epithelium activity and its cross-talk with spermatozoa, oocytes and preimplantation embryo and how these interactions affect fertilization and early embryo development.
Název v anglickém jazyce
From a Passive Conduit to Highly Dynamic Organ - What are the Roles of Uterine Tube Epithelium in Reproduction?
Popis výsledku anglicky
It is well known that the mammalian uterine tube (UT) plays a crucial role in female fertility, where the most important events leading to successful fertilization and pre-implantation embryo development occur. The known functions of these small intraabdominal organs are: an uptake and transport of oocytes; storage, transportation, and capacitation of spermatozoa, and finally fertilization and transport of the fertilized ovum and early embryo through the isthmus towards the uterotubal junction. The success of all these events depends on the interaction between the uterine tube epithelium (UTE) and gametes/embryo. Besides that, contemporary research revealed that the tubal epithelium provides essential nutritional support and the most suitable environment for early embryo development. Moreover, recent discoveries in molecular biology help understand the role of the epithelium at the cellular and molecular levels, highlighting the factors involved in regulating the UT signaling, that affects different steps in the fertilization process. According to the latest research, the extracellular vesicles, as a major component of tubal secretion, mediate the interaction between gametes/embryo and epithelium. This review aims to provide up-to-date knowledge on various aspects concerning tubal epithelium activity and its cross-talk with spermatozoa, oocytes and preimplantation embryo and how these interactions affect fertilization and early embryo development.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30214 - Obstetrics and gynaecology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
PHYSIOLOGICAL RESEARCH
ISSN
0862-8408
e-ISSN
1802-9973
Svazek periodika
71
Číslo periodika v rámci svazku
Suppl. 1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
10
Strana od-do
"S11"-"S20"
Kód UT WoS článku
000906713800003
EID výsledku v databázi Scopus
2-s2.0-85145491642