Clustering of Uterine Natural Killer Cells Around Uterine Glands in Women with Recurrent Implantation Failure and Recurrent Pregnancy Loss: An Immunohistochemical Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23310%2F25%3A43976425" target="_blank" >RIV/49777513:23310/25:43976425 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3390/ijms262010109" target="_blank" >http://dx.doi.org/10.3390/ijms262010109</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms262010109" target="_blank" >10.3390/ijms262010109</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clustering of Uterine Natural Killer Cells Around Uterine Glands in Women with Recurrent Implantation Failure and Recurrent Pregnancy Loss: An Immunohistochemical Study

Popis výsledku v původním jazyce

The immunological factor of sterility, specifically the abnormal count and activity of uterine NK (uNK) cells, may represent one of the potential contributors affecting specific subgroups of sterile couples undergoing assisted reproductive treatment (ART). Therefore, the primary purpose of the present paper was to assess uNK cell count. A total of 387 endometrial biopsies from patients with recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL) were analyzed to identify abnormalities in uNK cell count, using immunohistopathological evaluation. ANOVA analysis revealed a strong association with factor 0.161 with p-value &lt; 0.01, indicating that higher uNK cell count is associated with the presence of clusters (multicellular aggregates of uNK cells). These results suggest that the formation of clusters and the spatial distribution of uNK cells are significant factors in the context of the aforementioned clinical questions. However, the actual translational potential to clinical practice has not yet been established due to several challenges, namely: 1. the constantly changing definitions and diagnostic criteria for RIF and RPL, 2. varying sampling approaches for uNK cells, and 3. the historical lack of clear differentiation between uterine and peripheral NK cells. When all these issues are resolved, the observed tendency of uNK cells to form clusters will need to be a central focus of future investigations addressing RIF and RPL, thus improving ART outcomes.

Název v anglickém jazyce

Clustering of Uterine Natural Killer Cells Around Uterine Glands in Women with Recurrent Implantation Failure and Recurrent Pregnancy Loss: An Immunohistochemical Study

Popis výsledku anglicky

The immunological factor of sterility, specifically the abnormal count and activity of uterine NK (uNK) cells, may represent one of the potential contributors affecting specific subgroups of sterile couples undergoing assisted reproductive treatment (ART). Therefore, the primary purpose of the present paper was to assess uNK cell count. A total of 387 endometrial biopsies from patients with recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL) were analyzed to identify abnormalities in uNK cell count, using immunohistopathological evaluation. ANOVA analysis revealed a strong association with factor 0.161 with p-value &lt; 0.01, indicating that higher uNK cell count is associated with the presence of clusters (multicellular aggregates of uNK cells). These results suggest that the formation of clusters and the spatial distribution of uNK cells are significant factors in the context of the aforementioned clinical questions. However, the actual translational potential to clinical practice has not yet been established due to several challenges, namely: 1. the constantly changing definitions and diagnostic criteria for RIF and RPL, 2. varying sampling approaches for uNK cells, and 3. the historical lack of clear differentiation between uterine and peripheral NK cells. When all these issues are resolved, the observed tendency of uNK cells to form clusters will need to be a central focus of future investigations addressing RIF and RPL, thus improving ART outcomes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Molecular Sciences

ISSN

1661-6596

e-ISSN

1422-0067

Svazek periodika

26

Číslo periodika v rámci svazku

20

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

nestránkováno

Kód UT WoS článku

001603741700001

EID výsledku v databázi Scopus

2-s2.0-105020306785