The simple model of cell prestress maintained by cell incompressibility

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The simple model of cell prestress maintained by cell incompressibility

Popis výsledku v původním jazyce

Living cells are reinforced by polymer fibers (the so-called cytoskeleton) which are responsible for their mechanical behaviour. There are many evidences that these fibres are prestressed without an external load. To include this prestress into mechanical models of living tissues is not an easy task. We propose an approach in which the intracellular prestress is maintained by the incompressibility of cells. A simple illustrative structure is studied in order to determine the dependence of stiffness on the level of prestress. Some macroscopic models of living tissues with prestressed cells are formulated. The results show a clear dependence of the macroscopic mechanical response on the level of prestress at microscale. The model exhibits some features of living cells (prestress-induced stiffening, strain hardening).

Název v anglickém jazyce

The simple model of cell prestress maintained by cell incompressibility

Popis výsledku anglicky

Living cells are reinforced by polymer fibers (the so-called cytoskeleton) which are responsible for their mechanical behaviour. There are many evidences that these fibres are prestressed without an external load. To include this prestress into mechanical models of living tissues is not an easy task. We propose an approach in which the intracellular prestress is maintained by the incompressibility of cells. A simple illustrative structure is studied in order to determine the dependence of stiffness on the level of prestress. Some macroscopic models of living tissues with prestressed cells are formulated. The results show a clear dependence of the macroscopic mechanical response on the level of prestress at microscale. The model exhibits some features of living cells (prestress-induced stiffening, strain hardening).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mathematics and Computers in Simulation

ISSN

0378-4754

e-ISSN

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Svazek periodika

80

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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