Stereological tools for quantitative microscopy of the aortic wall with focus on the abdominal aortic aneurysm

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F10%3A00504689" target="_blank" >RIV/49777513:23520/10:00504689 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Stereological tools for quantitative microscopy of the aortic wall with focus on the abdominal aortic aneurysm

Popis výsledku v původním jazyce

In both normal and pathological histology of aorta, quantitative problems arise often as extensions of qualitative description and classification (e.g. classification of atherosclerosis, assessment of vulnerability of atherosclerotic lesions, leukocyte infiltration of tissue samples etc.). In this chapter we review and illustrate stereological methods currently available for quantification of histopathological changes in aortic abdominal aneurysms and for assessment of vulnerability of atherosclerotic lesions. Quantitative analysis requires unbiased sampling of tissue blocks. We demonstrate stereological quantification of vascular smooth muscle phenotype, leukocyte infiltration of aortic wall and mural thrombi, vascularisazion of the aneurysm and elastinolysis of the tunica media. Description of morphological properties of tissue specimen using continuous variables and systematic unbiased sampling permits us to apply standard statistical procedures and tests to morphometric data.

Název v anglickém jazyce

Stereological tools for quantitative microscopy of the aortic wall with focus on the abdominal aortic aneurysm

Popis výsledku anglicky

In both normal and pathological histology of aorta, quantitative problems arise often as extensions of qualitative description and classification (e.g. classification of atherosclerosis, assessment of vulnerability of atherosclerotic lesions, leukocyte infiltration of tissue samples etc.). In this chapter we review and illustrate stereological methods currently available for quantification of histopathological changes in aortic abdominal aneurysms and for assessment of vulnerability of atherosclerotic lesions. Quantitative analysis requires unbiased sampling of tissue blocks. We demonstrate stereological quantification of vascular smooth muscle phenotype, leukocyte infiltration of aortic wall and mural thrombi, vascularisazion of the aneurysm and elastinolysis of the tunica media. Description of morphological properties of tissue specimen using continuous variables and systematic unbiased sampling permits us to apply standard statistical procedures and tests to morphometric data.

Druh

C - Kapitola v odborné knize

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Microscopy: Science, Technology, Applications and Education

ISBN

978-84-614-6190-5

Počet stran výsledku

10

Strana od-do

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Počet stran knihy

2199

Název nakladatele

Formatex Research Center

Místo vydání

Badajoz

Kód UT WoS kapitoly

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