Simulation of contrast medium propagation based on 1D and 3D portal hemodynamics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F14%3A43922039" target="_blank" >RIV/49777513:23520/14:43922039 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Simulation of contrast medium propagation based on 1D and 3D portal hemodynamics

Popis výsledku v původním jazyce

The mathematical modelling of 3D blood flow coupled with contrast medium propagation in patient-specific human vessels ranks among the most computationally-demanding tasks, especially if a large vessel network is considered. With this in mind, some measure of simplification for potential use in clinical practice is usually inevitable and often also desired. In the present study, the main interest lies in the quantitative comparison between 3D and 1D models of portal hemodynamics and contrast medium propagation in two hepatic portal vein networks reconstructed from CT scans provided by the courtesy of the University Hospital Pilsen. To approximate the flow resistance of the downstream vascular bed and hepatic tissue, the mathematical model of Newtonian blood flow is coupled with the three-element Windkessel model. The numerical simulations of 3D and 1D blood flow and contrast medium propagation under average flow conditions are carried out using own in-house software. The obtained results show that, although the 1D model can never completely imitate the computational capabilities of the 3D model, its easy implementation, time-saving model preparation and almost no demands on computer technology dominate as advantages over obvious but moderate modelling errors arising from the dimensional reduction.

Název v anglickém jazyce

Simulation of contrast medium propagation based on 1D and 3D portal hemodynamics

Popis výsledku anglicky

The mathematical modelling of 3D blood flow coupled with contrast medium propagation in patient-specific human vessels ranks among the most computationally-demanding tasks, especially if a large vessel network is considered. With this in mind, some measure of simplification for potential use in clinical practice is usually inevitable and often also desired. In the present study, the main interest lies in the quantitative comparison between 3D and 1D models of portal hemodynamics and contrast medium propagation in two hepatic portal vein networks reconstructed from CT scans provided by the courtesy of the University Hospital Pilsen. To approximate the flow resistance of the downstream vascular bed and hepatic tissue, the mathematical model of Newtonian blood flow is coupled with the three-element Windkessel model. The numerical simulations of 3D and 1D blood flow and contrast medium propagation under average flow conditions are carried out using own in-house software. The obtained results show that, although the 1D model can never completely imitate the computational capabilities of the 3D model, its easy implementation, time-saving model preparation and almost no demands on computer technology dominate as advantages over obvious but moderate modelling errors arising from the dimensional reduction.

Druh

D - Stať ve sborníku

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

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Projekt

<a href="/cs/project/NT13326" target="_blank" >NT13326: Zvyšování resekability maligních ložiskových procesů pomocí metod zpřesňujících měření perfúzních parametrů zbytkového jaterního parenchymu - počítačem asistované diagnostiky a softwarového modelování</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Engineering Mechanics 2014

ISBN

978-80-214-4871-1

ISSN

1805-8248

e-ISSN

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Počet stran výsledku

4

Strana od-do

272-275

Název nakladatele

University of Technology

Místo vydání

Brno

Místo konání akce

Svratka

Datum konání akce

12. 5. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000364573900061