A mathematical model of the carp heart ventricle during the cardiac cycle

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F15%3A43925204" target="_blank" >RIV/49777513:23520/15:43925204 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/15:00444381 RIV/00216208:11140/15:10294777 RIV/49777513:23640/15:43925204

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jtbi.2015.03.014" target="_blank" >http://dx.doi.org/10.1016/j.jtbi.2015.03.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jtbi.2015.03.014" target="_blank" >10.1016/j.jtbi.2015.03.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A mathematical model of the carp heart ventricle during the cardiac cycle

Popis výsledku v původním jazyce

The poikilothermic heart has been suggested as a model for studying some of the mechanisms of early postnatal mammalian heart adaptations. We assessed morphological parameters of the carp heart (Cyprinus carpio L.) with diastolic dimensions: heart radius (5.73 mm), thickness of the compact (0.50 mm) and spongy myocardium (4.34 mm), in two conditions (systole, diastole): volume fraction of the compact myocardium (20.7% systole, 19.6% diastole), spongy myocardium (58.9% systole, 62.8% diastole), trabeculae (37.8% systole, 28.6% diastole), and cavities (41.5% systole, 51.9% diastole) within the ventricle; volume fraction of the trabeculae (64.1% systole, 45.5% diastole) and sinuses (35.9% systole, 54.5% diastole) within the spongy myocardium; ratio between the volume of compact and spongy myocardium (0.35 systole, 0.31 diastole); ratio between compact myocardium and trabeculae (0.55 systole, 0.69 diastole); and surface density of the trabeculae (0.095 ?m-1 systole, 0.147 ?m-1 diastole). We created a mathematical model of the carp heart based on actual morphometric data to simulate how the compact/spongy myocardium ratio, the permeability of the spongy myocardium, and sinus-trabeculae volume fractions within the spongy myocardium influence stroke volume, stroke work, ejection fraction and p-V diagram. Increasing permeability led to increasing and then decreasing stroke volume and work, and increasing ejection fraction. An increased amount of spongy myocardium led to an increased stroke volume, work, and ejection fraction. Varying sinus-trabeculae volume fractions within the spongy myocardium showed that an increased sinus volume fraction led to an increased stroke volume and work, and a decreased ejection fraction.

Název v anglickém jazyce

A mathematical model of the carp heart ventricle during the cardiac cycle

Popis výsledku anglicky

The poikilothermic heart has been suggested as a model for studying some of the mechanisms of early postnatal mammalian heart adaptations. We assessed morphological parameters of the carp heart (Cyprinus carpio L.) with diastolic dimensions: heart radius (5.73 mm), thickness of the compact (0.50 mm) and spongy myocardium (4.34 mm), in two conditions (systole, diastole): volume fraction of the compact myocardium (20.7% systole, 19.6% diastole), spongy myocardium (58.9% systole, 62.8% diastole), trabeculae (37.8% systole, 28.6% diastole), and cavities (41.5% systole, 51.9% diastole) within the ventricle; volume fraction of the trabeculae (64.1% systole, 45.5% diastole) and sinuses (35.9% systole, 54.5% diastole) within the spongy myocardium; ratio between the volume of compact and spongy myocardium (0.35 systole, 0.31 diastole); ratio between compact myocardium and trabeculae (0.55 systole, 0.69 diastole); and surface density of the trabeculae (0.095 ?m-1 systole, 0.147 ?m-1 diastole). We created a mathematical model of the carp heart based on actual morphometric data to simulate how the compact/spongy myocardium ratio, the permeability of the spongy myocardium, and sinus-trabeculae volume fractions within the spongy myocardium influence stroke volume, stroke work, ejection fraction and p-V diagram. Increasing permeability led to increasing and then decreasing stroke volume and work, and increasing ejection fraction. An increased amount of spongy myocardium led to an increased stroke volume, work, and ejection fraction. Varying sinus-trabeculae volume fractions within the spongy myocardium showed that an increased sinus volume fraction led to an increased stroke volume and work, and a decreased ejection fraction.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF THEORETICAL BIOLOGY

ISSN

0022-5193

e-ISSN

—

Svazek periodika

373

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

14

Strana od-do

12-25

Kód UT WoS článku

000354002800002

EID výsledku v databázi Scopus

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