Using meta-differential evolution to enhance a calculation of a continuous blood glucose level

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F16%3A43929001" target="_blank" >RIV/49777513:23520/16:43929001 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cmpb.2016.05.011" target="_blank" >http://dx.doi.org/10.1016/j.cmpb.2016.05.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmpb.2016.05.011" target="_blank" >10.1016/j.cmpb.2016.05.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Using meta-differential evolution to enhance a calculation of a continuous blood glucose level

Popis výsledku v původním jazyce

We developed a new model of glucose dynamics. The model calculates blood glucose level as a function of transcapillary glucose transport. In previous studies, we validated the model with animal experiments. We used analytical method to determine model parameters. In this study, we validate the model with subjects with type 1 diabetes. In addition, we combine the analytic method with meta-differential evolution. To validate the model with human patients, we obtained a data set of type 1 diabetes study that was coordinated by Jaeb Center for Health Research. We calculated a continuous blood glucose level from continuously measured interstitial fluid glucose level. We used 6 different scenarios to ensure robust validation of the calculation. Over 96% of calculated blood glucose levels fit A+B zones of the Clarke Error Grid. No data set required any correction of model parameters during the time course of measuring. We successfully verified the possibility of calculating a continuous blood glucose level of subjects with type 1 diabetes. This study signals a successful transition of our research from an animal experiment to a human patient. Researchers can test our model with their data on-line at https://diabetes.zcu.cz.

Název v anglickém jazyce

Using meta-differential evolution to enhance a calculation of a continuous blood glucose level

Popis výsledku anglicky

We developed a new model of glucose dynamics. The model calculates blood glucose level as a function of transcapillary glucose transport. In previous studies, we validated the model with animal experiments. We used analytical method to determine model parameters. In this study, we validate the model with subjects with type 1 diabetes. In addition, we combine the analytic method with meta-differential evolution. To validate the model with human patients, we obtained a data set of type 1 diabetes study that was coordinated by Jaeb Center for Health Research. We calculated a continuous blood glucose level from continuously measured interstitial fluid glucose level. We used 6 different scenarios to ensure robust validation of the calculation. Over 96% of calculated blood glucose levels fit A+B zones of the Clarke Error Grid. No data set required any correction of model parameters during the time course of measuring. We successfully verified the possibility of calculating a continuous blood glucose level of subjects with type 1 diabetes. This study signals a successful transition of our research from an animal experiment to a human patient. Researchers can test our model with their data on-line at https://diabetes.zcu.cz.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/LO1506" target="_blank" >LO1506: Podpora udržitelnosti centra NTIS - Nové technologie pro informační společnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Computer Methods and Programs in Biomedicine

ISSN

0169-2607

e-ISSN

—

Svazek periodika

133

Číslo periodika v rámci svazku

September 2016

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

45-54

Kód UT WoS článku

000379649600007

EID výsledku v databázi Scopus

2-s2.0-84973100962