The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F17%3A43931702" target="_blank" >RIV/49777513:23520/17:43931702 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10358993 RIV/00216208:11140/17:10358993 RIV/00064203:_____/17:10358993

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aanat.2017.03.004" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2017.03.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aanat.2017.03.004" target="_blank" >10.1016/j.aanat.2017.03.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps

Popis výsledku v původním jazyce

Human cryopreserved allografts of pulmonary and aortic heart valves, aortas and pulmonary trunks are used for valve replacement. However, it is unknown how the composition of these allografts relate to their mechanical properties. Our aims were to correlate the histological compositions and passive mechanical properties of aortic and pulmonary valves and to observe the microcracks of aortas and pulmonary trunks. The following parameters were quantified: ultimate stress; ultimate strain; Young’s modulus of elasticity; valve cusp wall thickness; pulmonary and aortic intima-media thickness; area fraction of elastin, collagen and calcification; and length density of elastic fibres. The propagation of experimentally induced microcracks avoided elastic fibres. Ultimate strain was negatively correlated with the area fraction of calcification (r =−0.4) in aortas. Ultimate stress (r = 0.27) and Young’s modulus in small deformation (r = 0.29) and in large deformation (r = 0.32) correlated with wall thickness in valve cusps. Young’s modulus (r = 0.34) and ultimate strain (r = 0.31) correlated with intima-media thickness. Ultimate strain correlated with the area fraction of elastin (r = −0.40) and collagen in the arteries (r = 0.31). As conventional histology does not fully explain the mechanical properties of cryopreserved grafts, both morphological and biomechanical tests should be used complementarily when characterizing the ageing of the grafts.

Název v anglickém jazyce

The composition and biomechanical properties of human cryopreserved aortas, pulmonary trunks, and aortic and pulmonary cusps

Popis výsledku anglicky

Human cryopreserved allografts of pulmonary and aortic heart valves, aortas and pulmonary trunks are used for valve replacement. However, it is unknown how the composition of these allografts relate to their mechanical properties. Our aims were to correlate the histological compositions and passive mechanical properties of aortic and pulmonary valves and to observe the microcracks of aortas and pulmonary trunks. The following parameters were quantified: ultimate stress; ultimate strain; Young’s modulus of elasticity; valve cusp wall thickness; pulmonary and aortic intima-media thickness; area fraction of elastin, collagen and calcification; and length density of elastic fibres. The propagation of experimentally induced microcracks avoided elastic fibres. Ultimate strain was negatively correlated with the area fraction of calcification (r =−0.4) in aortas. Ultimate stress (r = 0.27) and Young’s modulus in small deformation (r = 0.29) and in large deformation (r = 0.32) correlated with wall thickness in valve cusps. Young’s modulus (r = 0.34) and ultimate strain (r = 0.31) correlated with intima-media thickness. Ultimate strain correlated with the area fraction of elastin (r = −0.40) and collagen in the arteries (r = 0.31). As conventional histology does not fully explain the mechanical properties of cryopreserved grafts, both morphological and biomechanical tests should be used complementarily when characterizing the ageing of the grafts.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20503 - Textiles; including synthetic dyes, colours, fibres (nanoscale materials to be 2.10; biomaterials to be 2.9)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

ISSN

0940-9602

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

212

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

17-26

Kód UT WoS článku

000405057500004

EID výsledku v databázi Scopus

2-s2.0-85018286720