SmartCGMS as an Environment for an Insulin-Pump Development with FDA-Accepted In-Silico Pre-Clinical Trials

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F19%3A43957389" target="_blank" >RIV/49777513:23520/19:43957389 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.procs.2019.11.084" target="_blank" >http://dx.doi.org/10.1016/j.procs.2019.11.084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.procs.2019.11.084" target="_blank" >10.1016/j.procs.2019.11.084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

SmartCGMS as an Environment for an Insulin-Pump Development with FDA-Accepted In-Silico Pre-Clinical Trials

Popis výsledku v původním jazyce

Diabetes is a widespread civilization disease. It manifests with an elevated blood glucose level. In the long-term, elevated blood glucose level continuously damages organs. In the short-term, hypo- and hyperglycemia are acute complications. Insulin lowers blood glucose level by promoting its utilization. At basal rate, insulin pump delivers insulin to subcutaneous tissue to control blood glucose level. In addition, patient doses insulin boluses in accordance with estimated carbohydrate content of consumed meal. Control algorithm of the pump considers the boluses, when calculating the basal rate. In our previous work, we have proposed a parallel-architecture for the next-generation of glucose monitoring - SmartCGMS. It unifies the source-code base and the glucose-monitoring-and-control paradigm across real, simulated and prototyped devices. As the development continues, especially towards the pump-control algorithms, we face a problem of reducing the SmartCGMS requirements when considering a low-power hardware. In this paper, we present the modifications that lead to a reduced number of threads, while implementing the closed-loop feedback between a glucose sensor and insulin pump to conduct FDA accepted in-silico pre-clinical trials.

Název v anglickém jazyce

SmartCGMS as an Environment for an Insulin-Pump Development with FDA-Accepted In-Silico Pre-Clinical Trials

Popis výsledku anglicky

Diabetes is a widespread civilization disease. It manifests with an elevated blood glucose level. In the long-term, elevated blood glucose level continuously damages organs. In the short-term, hypo- and hyperglycemia are acute complications. Insulin lowers blood glucose level by promoting its utilization. At basal rate, insulin pump delivers insulin to subcutaneous tissue to control blood glucose level. In addition, patient doses insulin boluses in accordance with estimated carbohydrate content of consumed meal. Control algorithm of the pump considers the boluses, when calculating the basal rate. In our previous work, we have proposed a parallel-architecture for the next-generation of glucose monitoring - SmartCGMS. It unifies the source-code base and the glucose-monitoring-and-control paradigm across real, simulated and prototyped devices. As the development continues, especially towards the pump-control algorithms, we face a problem of reducing the SmartCGMS requirements when considering a low-power hardware. In this paper, we present the modifications that lead to a reduced number of threads, while implementing the closed-loop feedback between a glucose sensor and insulin pump to conduct FDA accepted in-silico pre-clinical trials.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

<a href="/cs/project/LO1506" target="_blank" >LO1506: Podpora udržitelnosti centra NTIS - Nové technologie pro informační společnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Procedia Computer Science

ISBN

—

ISSN

1877-0509

e-ISSN

—

Počet stran výsledku

8

Strana od-do

322-329

Název nakladatele

Elsevier

Místo vydání

—

Místo konání akce

Coimbra, Portugal

Datum konání akce

4. 11. 2019

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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