On the relevance of boundary conditions and viscosity models in blood flow simulations in patient‐specific aorto‐coronary bypass models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F21%3A43960788" target="_blank" >RIV/49777513:23520/21:43960788 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/cnm.3439" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/cnm.3439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cnm.3439" target="_blank" >10.1002/cnm.3439</a>

Jazyk výsledku

angličtina

Název v původním jazyce

On the relevance of boundary conditions and viscosity models in blood flow simulations in patient‐specific aorto‐coronary bypass models

Popis výsledku v původním jazyce

Physiologically realistic results are the aim of every blood flowsimulation. This is not different in aorto‐coronary bypasses where the properties of the coronary circulation may significantly affect the relevance of the performed simulations. By considering three patient‐specific bypass geometries, the present paper focuses on two aspects of the coronary blood flow—its phasic flow pattern and its behaviour affected by blood rheology. For the phasic flow property, a multiscale modelling approach is chosen as a means to assess the ability of five different types of coronary boundary conditions (mean arterial pressure, Windkessel model and three lumped parameter models) to attain realistic coronary hemodynamics. From the analysed variants of boundary conditions, the best option in terms of physiological characteristics and its potential for use in patient‐based simulations, is utilised to account for the effect of shear‐dependent viscosity on the resulting hemodynamics and wall shear stress stimulation. Aside from the Newtonian model, the blood rheology is approximated by two non‐Newtonian models in order to determine whether the choice of a viscosity model is important in simulations involving coronary circulation. A comprehensive analysis of obtained results demonstrated notable superiority of all lumped parameter models, especially in comparison to the constant outlet pressure, which regardless of bypass type gave overestimated and physiologically misleading results. In terms of rheology, it was noted that blood in undamaged coronary arteries behaves as a Newtonian fluid, whereas in vessels with atypical lumen geometry, such as that of anastomosis or stenosis, its shear‐thinning behaviour should not be ignored.

Název v anglickém jazyce

On the relevance of boundary conditions and viscosity models in blood flow simulations in patient‐specific aorto‐coronary bypass models

Popis výsledku anglicky

Physiologically realistic results are the aim of every blood flowsimulation. This is not different in aorto‐coronary bypasses where the properties of the coronary circulation may significantly affect the relevance of the performed simulations. By considering three patient‐specific bypass geometries, the present paper focuses on two aspects of the coronary blood flow—its phasic flow pattern and its behaviour affected by blood rheology. For the phasic flow property, a multiscale modelling approach is chosen as a means to assess the ability of five different types of coronary boundary conditions (mean arterial pressure, Windkessel model and three lumped parameter models) to attain realistic coronary hemodynamics. From the analysed variants of boundary conditions, the best option in terms of physiological characteristics and its potential for use in patient‐based simulations, is utilised to account for the effect of shear‐dependent viscosity on the resulting hemodynamics and wall shear stress stimulation. Aside from the Newtonian model, the blood rheology is approximated by two non‐Newtonian models in order to determine whether the choice of a viscosity model is important in simulations involving coronary circulation. A comprehensive analysis of obtained results demonstrated notable superiority of all lumped parameter models, especially in comparison to the constant outlet pressure, which regardless of bypass type gave overestimated and physiologically misleading results. In terms of rheology, it was noted that blood in undamaged coronary arteries behaves as a Newtonian fluid, whereas in vessels with atypical lumen geometry, such as that of anastomosis or stenosis, its shear‐thinning behaviour should not be ignored.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20302 - Applied mechanics

Projekt

<a href="/cs/project/EF17_048%2F0007280" target="_blank" >EF17_048/0007280: Aplikace moderních technologií v medicíně a průmyslu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal for Numerical Methods in Biomedical Engineering

ISSN

2040-7939

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

30

Strana od-do

—

Kód UT WoS článku

000613994300001

EID výsledku v databázi Scopus

2-s2.0-85100234064