Self-assembly of hydrophobically modified hyaluronic acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F21%3A43962185" target="_blank" >RIV/49777513:23640/21:43962185 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/21:PU139345

Výsledek na webu

<a href="https://doi.org/10.1016/j.apsusc.2021.149161" target="_blank" >https://doi.org/10.1016/j.apsusc.2021.149161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2021.149161" target="_blank" >10.1016/j.apsusc.2021.149161</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-assembly of hydrophobically modified hyaluronic acid

Popis výsledku v původním jazyce

The understanding how physicochemical properties of amphiphilic molecules influence the self-assembly process is crucial to control their final nanostructure. Furthermore, the relationship between the supramolecular structure and functional properties is of utmost importance for effective design towards specific applications. The hydrophobically modified hyaluronic acid was investigated as a representative of semi-flexible amphiphilic polyelectrolyte with the tremendous biomedical potential. The essential physicochemical characteristics were extracted from the interplay of multiple techniques such as rheology, fluorescence, dynamic light scattering, surface tension, and small-angle X-ray scattering. The correlation of used techniques allowed us to determine the size of hydrophobic domains and showed that aggregate size decrease with increasing chain flexibility. Furthermore, the ratio between the size of aggregates and hydrophobic domains was found to be crucial for curcumin loading efficiency and in vitro skin penetration. Moreover, critical aggregation concentration was determined using various techniques. However, aggregates were found below these concentrations. The rheological characterization identified different dynamical regimes that can define the preparation and application concentration range. The acquired supramolecular structureproperty function provides valuable information for the design of self-assembled nanostructures.

Název v anglickém jazyce

Self-assembly of hydrophobically modified hyaluronic acid

Popis výsledku anglicky

The understanding how physicochemical properties of amphiphilic molecules influence the self-assembly process is crucial to control their final nanostructure. Furthermore, the relationship between the supramolecular structure and functional properties is of utmost importance for effective design towards specific applications. The hydrophobically modified hyaluronic acid was investigated as a representative of semi-flexible amphiphilic polyelectrolyte with the tremendous biomedical potential. The essential physicochemical characteristics were extracted from the interplay of multiple techniques such as rheology, fluorescence, dynamic light scattering, surface tension, and small-angle X-ray scattering. The correlation of used techniques allowed us to determine the size of hydrophobic domains and showed that aggregate size decrease with increasing chain flexibility. Furthermore, the ratio between the size of aggregates and hydrophobic domains was found to be crucial for curcumin loading efficiency and in vitro skin penetration. Moreover, critical aggregation concentration was determined using various techniques. However, aggregates were found below these concentrations. The rheological characterization identified different dynamical regimes that can define the preparation and application concentration range. The acquired supramolecular structureproperty function provides valuable information for the design of self-assembled nanostructures.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

APPLIED SURFACE SCIENCE

ISSN

0169-4332

e-ISSN

—

Svazek periodika

546

Číslo periodika v rámci svazku

APR 30 2021

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000620364900006

EID výsledku v databázi Scopus

2-s2.0-85100265552