Chitosan and its derivatives as nanotheranostics in multiple diseases management: a clinical perspective

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23640%2F25%3A43976027" target="_blank" >RIV/49777513:23640/25:43976027 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.carbpol.2025.123852" target="_blank" >https://doi.org/10.1016/j.carbpol.2025.123852</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2025.123852" target="_blank" >10.1016/j.carbpol.2025.123852</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chitosan and its derivatives as nanotheranostics in multiple diseases management: a clinical perspective

Popis výsledku v původním jazyce

Chitosan, a biopolymer derived from chitin, has garnered substantial scrutiny in recent times, attributable to its versatile properties, including biodegradability, biocompatibility, and non-toxicity. These characteristics make it an ideal candidate for various medical applications, particularly in the field of nanomedicine. This review explores the emerging role of chitosan and its derivatives in nanotheranostics, which combines therapeutic and diagnostic modalities for the treatment of multiple diseases. The prospect of chitosan-based nanoparticles in the delivery of drugs, vector delivery, imaging, and disease monitoring has been extensively explored. The modification of chitosan with various functional groups, such as chitosan oligosaccharides, thiolated chitosan, carboxymethyl chitosan, glycol chitosan and other derivatives, enhances its pharmacokinetic properties, targeting capabilities, and therapeutic efficacy. Chitosan-based nanocarriers have shown potential in treating various conditions, including cancer, inflammation, infectious diseases, and neurodegenerative disorders, by improvingthe solubility of drugs, stability, and controlled release. Additionally, chitosan has a theranostic role in imaging approaches such as optical imaging, ultrasound, and photoacoustic imaging, facilitating early diagnosis and monitoring of therapeutic responses. This review also addresses the disputes and future perceptions for the development of chitosan-based nanotheranostics, including issues related to scalability, regulatory approval, and long-term safety.

Název v anglickém jazyce

Chitosan and its derivatives as nanotheranostics in multiple diseases management: a clinical perspective

Popis výsledku anglicky

Chitosan, a biopolymer derived from chitin, has garnered substantial scrutiny in recent times, attributable to its versatile properties, including biodegradability, biocompatibility, and non-toxicity. These characteristics make it an ideal candidate for various medical applications, particularly in the field of nanomedicine. This review explores the emerging role of chitosan and its derivatives in nanotheranostics, which combines therapeutic and diagnostic modalities for the treatment of multiple diseases. The prospect of chitosan-based nanoparticles in the delivery of drugs, vector delivery, imaging, and disease monitoring has been extensively explored. The modification of chitosan with various functional groups, such as chitosan oligosaccharides, thiolated chitosan, carboxymethyl chitosan, glycol chitosan and other derivatives, enhances its pharmacokinetic properties, targeting capabilities, and therapeutic efficacy. Chitosan-based nanocarriers have shown potential in treating various conditions, including cancer, inflammation, infectious diseases, and neurodegenerative disorders, by improvingthe solubility of drugs, stability, and controlled release. Additionally, chitosan has a theranostic role in imaging approaches such as optical imaging, ultrasound, and photoacoustic imaging, facilitating early diagnosis and monitoring of therapeutic responses. This review also addresses the disputes and future perceptions for the development of chitosan-based nanotheranostics, including issues related to scalability, regulatory approval, and long-term safety.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CARBOHYDRATE POLYMERS

ISSN

0144-8617

e-ISSN

1879-1344

Svazek periodika

366

Číslo periodika v rámci svazku

OCT 15 2025

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

28

Strana od-do

nestránkováno

Kód UT WoS článku

001510788400003

EID výsledku v databázi Scopus

2-s2.0-105007707325