Aluminofluoride Complexes: Phosphate Analogues and a Hidden Hazard

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Aluminofluoride Complexes: Phosphate Analogues and a Hidden Hazard

Popis výsledku v původním jazyce

There is a burgeoning body of evidence that aluminum can be implicated as an etiological factor of several neuropathological events. The molecular mechanisms underlying aluminum toxicity are still poorly understood. Reflecting on many studies, we suggesta new view on the toxicity of aluminum in a link with fluoride. Soluble aluminofluoride complexes - fluoroaluminate (AlFx) are formed in water solutions containing fluoride and traces of aluminum. These complexes are able to simulate phosphate groups inmany biochemical reactions. AlFx are used in many laboratory investigations of guanine nucleotide binding proteins (G proteins). They affect various enzyme activities and cell signaling cascades. The hidden danger of a long-term synergistic action of aluminum and fluoride is not fully recognized at this point. We suggest that aluminum and fluoride can exacerbate the pathological and clinical problems, namely by interfering with a great number of G-protein-dependent cellular mechanisms,

Název v anglickém jazyce

Aluminofluoride Complexes: Phosphate Analogues and a Hidden Hazard

Popis výsledku anglicky

There is a burgeoning body of evidence that aluminum can be implicated as an etiological factor of several neuropathological events. The molecular mechanisms underlying aluminum toxicity are still poorly understood. Reflecting on many studies, we suggesta new view on the toxicity of aluminum in a link with fluoride. Soluble aluminofluoride complexes - fluoroaluminate (AlFx) are formed in water solutions containing fluoride and traces of aluminum. These complexes are able to simulate phosphate groups inmany biochemical reactions. AlFx are used in many laboratory investigations of guanine nucleotide binding proteins (G proteins). They affect various enzyme activities and cell signaling cascades. The hidden danger of a long-term synergistic action of aluminum and fluoride is not fully recognized at this point. We suggest that aluminum and fluoride can exacerbate the pathological and clinical problems, namely by interfering with a great number of G-protein-dependent cellular mechanisms,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Inorganic Chemistry

ISSN

1877-9441

e-ISSN

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Svazek periodika

2012

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

8-18

Kód UT WoS článku

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EID výsledku v databázi Scopus

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