Highly toxic ribosome-inactivating proteins as chemical warfare of terrorist agents

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F18%3A43897789" target="_blank" >RIV/60076658:12110/18:43897789 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.31482/mmsl.2018.027" target="_blank" >http://dx.doi.org/10.31482/mmsl.2018.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.31482/mmsl.2018.027" target="_blank" >10.31482/mmsl.2018.027</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Highly toxic ribosome-inactivating proteins as chemical warfare of terrorist agents

Popis výsledku v původním jazyce

Biological weapons include infectious agents and toxins. Toxins are poisons produced by living organisms. An important group of toxins are ribosome inactivating proteins (RIPs) of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. RIPs have been of great scientific interest due to their importance in human health, as both pathogenic agents and therapeutics, but also due to their potential use in biological warfare and bioterrorism. RIPs relevant to bioterrorism include mainly ricin and abrin. Ricin is protein produced in the seeds of the castor oil plant (Ricinus communis). Abrin is protein that has been isolated from the seeds of Abrus precatorius. Both inactivate ribosomes, which results in toxicity because of the inhibition of protein synthesis. Abrin and ricin are substances very toxic to humans in all types of administration, with the exception of oral administration. Symptoms include nausea, diarrhea, tachycardia, hypotension, and seizures. Treatment is supportive, and no antidote exists.

Název v anglickém jazyce

Highly toxic ribosome-inactivating proteins as chemical warfare of terrorist agents

Popis výsledku anglicky

Biological weapons include infectious agents and toxins. Toxins are poisons produced by living organisms. An important group of toxins are ribosome inactivating proteins (RIPs) of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. RIPs have been of great scientific interest due to their importance in human health, as both pathogenic agents and therapeutics, but also due to their potential use in biological warfare and bioterrorism. RIPs relevant to bioterrorism include mainly ricin and abrin. Ricin is protein produced in the seeds of the castor oil plant (Ricinus communis). Abrin is protein that has been isolated from the seeds of Abrus precatorius. Both inactivate ribosomes, which results in toxicity because of the inhibition of protein synthesis. Abrin and ricin are substances very toxic to humans in all types of administration, with the exception of oral administration. Symptoms include nausea, diarrhea, tachycardia, hypotension, and seizures. Treatment is supportive, and no antidote exists.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Vojenské zdravotnické listy - Military Medical Science Letters

ISSN

0372-7025

e-ISSN

—

Svazek periodika

87

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

158-168

Kód UT WoS článku

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EID výsledku v databázi Scopus

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