Palytoxin

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Palytoxin

Popis výsledku v původním jazyce

Palytoxin (PLTX) is a lethal, heat-stable marine toxin, which was first isolated in 1971 in Hawaii from the seaweed-like coral, Limu-make-o-Hana (Seaweed of Death from Hana), polyps of the genus Palythoa [2]. Later identified as Palythoa toxica, a zoanthid of the tropical areas of the Pacific Ocean, PLTX is a marine polyalcohol toxin with a very large and complex chemical structure that has both lipophilic and hydrophilic moieties. PLTX and its analogues have been implicated in toxic events in humans following ingestion, dermal exposure, or inhalation of vapors, and in animals following various routes of administration [4]. Moreover, PLTX and its analogues exert their potent biological activity by altering normal ion homeostasis in excitable and nonexcitable tissues. The toxin depolarizes mammalian cells by causing cation conductance with relatively low ion selectivity.

Název v anglickém jazyce

Palytoxin

Popis výsledku anglicky

Palytoxin (PLTX) is a lethal, heat-stable marine toxin, which was first isolated in 1971 in Hawaii from the seaweed-like coral, Limu-make-o-Hana (Seaweed of Death from Hana), polyps of the genus Palythoa [2]. Later identified as Palythoa toxica, a zoanthid of the tropical areas of the Pacific Ocean, PLTX is a marine polyalcohol toxin with a very large and complex chemical structure that has both lipophilic and hydrophilic moieties. PLTX and its analogues have been implicated in toxic events in humans following ingestion, dermal exposure, or inhalation of vapors, and in animals following various routes of administration [4]. Moreover, PLTX and its analogues exert their potent biological activity by altering normal ion homeostasis in excitable and nonexcitable tissues. The toxin depolarizes mammalian cells by causing cation conductance with relatively low ion selectivity.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30108 - Toxicology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of Foodborne Diseases

ISBN

978-1-138-03630-7

Počet stran výsledku

7

Strana od-do

1035-1041

Počet stran knihy

1192

Název nakladatele

CRC Press

Místo vydání

Spojené státy americké

Kód UT WoS kapitoly

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