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Distribution of adh1b genotypes predisposed to enhanced alcohol consumption in the Czech roma/gypsy population

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F18%3A43898332" target="_blank" >RIV/60076658:12110/18:43898332 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00023001:_____/18:00077631 RIV/68407700:21460/18:00340653

  • Výsledek na webu

    <a href="http://dx.doi.org/10.21101/cejph.a5090" target="_blank" >http://dx.doi.org/10.21101/cejph.a5090</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.21101/cejph.a5090" target="_blank" >10.21101/cejph.a5090</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Distribution of adh1b genotypes predisposed to enhanced alcohol consumption in the Czech roma/gypsy population

  • Popis výsledku v původním jazyce

    Objective: The aim of the study was to analyse the frequencies of rs1229984 genotypes within the alcohol dehydrogenase (ADH1B) gene in a Gypsies/Roma population and compare them with other populations and with ethanol consumption. Methods: We analysed the ADH1B (rs1229984; Arg47→His; c.143G&gt;A) genotype using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in two ethnically different groups – Gypsies/Roma (N = 301) and Czechs (N = 300) where one day alcohol consumption was recorded. Results: ADH1B genotype/allelic frequencies did not significantly differ between the populations (p = 0.32). The frequency of minor A allele carriers was slightly higher in Gypsies/Roma (14.7%) than in Czechs (11.9%). The prevalence of subjects reporting alcohol intake on the previous day was non-significantly lower in Gypsies/Roma (10.5% vs. 16.4%), as was the amount of alcohol consumed the day before the examination in ethanol consumers (36.1 ± 18.3 g vs. 43.0 ± 27.2 g). Conclusions: The frequency of rs1229984 genotypes in the ADH1B gene within the Gypsies/Roma population corresponds with frequencies obtained in North India/Central Asia, the putative country of this ethnic origin. Our results suggest that the minority Gypsies/Roma population consume slightly less alcohol than the Czech majority population. © 2018, Czech National Institute of Public Health. All rights reserved.

  • Název v anglickém jazyce

    Distribution of adh1b genotypes predisposed to enhanced alcohol consumption in the Czech roma/gypsy population

  • Popis výsledku anglicky

    Objective: The aim of the study was to analyse the frequencies of rs1229984 genotypes within the alcohol dehydrogenase (ADH1B) gene in a Gypsies/Roma population and compare them with other populations and with ethanol consumption. Methods: We analysed the ADH1B (rs1229984; Arg47→His; c.143G&gt;A) genotype using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) in two ethnically different groups – Gypsies/Roma (N = 301) and Czechs (N = 300) where one day alcohol consumption was recorded. Results: ADH1B genotype/allelic frequencies did not significantly differ between the populations (p = 0.32). The frequency of minor A allele carriers was slightly higher in Gypsies/Roma (14.7%) than in Czechs (11.9%). The prevalence of subjects reporting alcohol intake on the previous day was non-significantly lower in Gypsies/Roma (10.5% vs. 16.4%), as was the amount of alcohol consumed the day before the examination in ethanol consumers (36.1 ± 18.3 g vs. 43.0 ± 27.2 g). Conclusions: The frequency of rs1229984 genotypes in the ADH1B gene within the Gypsies/Roma population corresponds with frequencies obtained in North India/Central Asia, the putative country of this ethnic origin. Our results suggest that the minority Gypsies/Roma population consume slightly less alcohol than the Czech majority population. © 2018, Czech National Institute of Public Health. All rights reserved.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30101 - Human genetics

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/LD14114" target="_blank" >LD14114: Obesita a nadváha u romské minority v Jihočeském kraji</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Central European Journal of Public Health

  • ISSN

    1210-7778

  • e-ISSN

  • Svazek periodika

    26

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    CZ - Česká republika

  • Počet stran výsledku

    5

  • Strana od-do

    284-288

  • Kód UT WoS článku

    000463167100007

  • EID výsledku v databázi Scopus

    2-s2.0-85060137955