Analysis of the fall‐related risk of pharmacotherapy in Czech hospitals: A case control study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F19%3A43899806" target="_blank" >RIV/60076658:12110/19:43899806 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11160/20:10407904
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/jep.13270" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/jep.13270</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jep.13270" target="_blank" >10.1111/jep.13270</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Analysis of the fall‐related risk of pharmacotherapy in Czech hospitals: A case control study
Popis výsledku v původním jazyce
Falls are among the major problems occurring in hospital setting, when drugs are viewed as important modifiable risk factor of falling. The aim was to analyse the effect of pharmacotherapy on the risk of falls in hospitalized patients. Methods A multicentre prospective case‐control study was conducted in 2017 retrieving data from four hospitals in South Bohemia, Czech Republic. An online database was constructed to collect patient and fall‐related data. Each fall that occurred during hospitalization was assigned to appropriate controls (no fall during hospitalization) based on gender, age, length of hospitalization, and the number of drugs. Univariate and multivariate correlations were performed with a significance level of P < .05. Results A total of 222 fall cases (107 males; median age, 81 y) and 1076 controls (516 males; median age, 80 y) were included. According to the first ATC level classification, drugs from groups S, N, and P were significantly associated with fall‐related risk compared with controls (P < .05); further analysis of ATC levels showed that only psycholeptics (N05), antipsychotics (N05A), and tiapride were significantly associated with falls. Regression analysis revealed use of psycholeptics N05 (OR = 2.06; 95% CI, 1.56‐2.76), or ophthalmologicals S01 (OR = 2.72; 95% CI, 1.37‐5.41), as factors with the highest fall‐related risk. Conclusions Apart from the commonly considered fall‐risk increasing drugs, other groups, such as ophthalmologicals, should also be considered; however, regarding clinical practice, it is difficult to evaluate the effects of individual drugs in the context of other risk factors of falls, due to the multifactorial nature of falls.
Název v anglickém jazyce
Analysis of the fall‐related risk of pharmacotherapy in Czech hospitals: A case control study
Popis výsledku anglicky
Falls are among the major problems occurring in hospital setting, when drugs are viewed as important modifiable risk factor of falling. The aim was to analyse the effect of pharmacotherapy on the risk of falls in hospitalized patients. Methods A multicentre prospective case‐control study was conducted in 2017 retrieving data from four hospitals in South Bohemia, Czech Republic. An online database was constructed to collect patient and fall‐related data. Each fall that occurred during hospitalization was assigned to appropriate controls (no fall during hospitalization) based on gender, age, length of hospitalization, and the number of drugs. Univariate and multivariate correlations were performed with a significance level of P < .05. Results A total of 222 fall cases (107 males; median age, 81 y) and 1076 controls (516 males; median age, 80 y) were included. According to the first ATC level classification, drugs from groups S, N, and P were significantly associated with fall‐related risk compared with controls (P < .05); further analysis of ATC levels showed that only psycholeptics (N05), antipsychotics (N05A), and tiapride were significantly associated with falls. Regression analysis revealed use of psycholeptics N05 (OR = 2.06; 95% CI, 1.56‐2.76), or ophthalmologicals S01 (OR = 2.72; 95% CI, 1.37‐5.41), as factors with the highest fall‐related risk. Conclusions Apart from the commonly considered fall‐risk increasing drugs, other groups, such as ophthalmologicals, should also be considered; however, regarding clinical practice, it is difficult to evaluate the effects of individual drugs in the context of other risk factors of falls, due to the multifactorial nature of falls.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30302 - Epidemiology
Návaznosti výsledku
Projekt
<a href="/cs/project/NV16-33463A" target="_blank" >NV16-33463A: Analýza faktorů ovlivňujících riziko pádů - možnosti zapojení sester a farmaceutů do minimalizace tohoto rizika</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Evaluation in Clinical Practice
ISSN
1356-1294
e-ISSN
—
Svazek periodika
25
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
1-10
Kód UT WoS článku
000484719400001
EID výsledku v databázi Scopus
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