Cyclosporine A: Chemistry and Toxicity – A Review
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F21%3A43901356" target="_blank" >RIV/60076658:12110/21:43901356 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62690094:18470/21:50018167 RIV/00179906:_____/21:10430032
Výsledek na webu
<a href="https://www.eurekaselect.com/186667/article" target="_blank" >https://www.eurekaselect.com/186667/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867327666201006153202" target="_blank" >10.2174/0929867327666201006153202</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cyclosporine A: Chemistry and Toxicity – A Review
Popis výsledku v původním jazyce
Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly improved the survival rates of patients and grafts after solidorgan transplantation. Unfortunately, CsA administration can be associated with a number of side effects due to its high toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important to understand the serious side effects of CsA in patients, especially in transplantation. In this review article, we are summarizing the chemistry and most known toxic effects of CsA including the nephrotoxic, hepatotoxic, neurotoxic and cardiotoxic effects. Its available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the molecular pathways of toxic damage induced by CsA are also detailly discussed. We hope that this review will help to further understand the source, chemistry and clinical application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.
Název v anglickém jazyce
Cyclosporine A: Chemistry and Toxicity – A Review
Popis výsledku anglicky
Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly improved the survival rates of patients and grafts after solidorgan transplantation. Unfortunately, CsA administration can be associated with a number of side effects due to its high toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important to understand the serious side effects of CsA in patients, especially in transplantation. In this review article, we are summarizing the chemistry and most known toxic effects of CsA including the nephrotoxic, hepatotoxic, neurotoxic and cardiotoxic effects. Its available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the molecular pathways of toxic damage induced by CsA are also detailly discussed. We hope that this review will help to further understand the source, chemistry and clinical application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30107 - Medicinal chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GA17-19968S" target="_blank" >GA17-19968S: Lokalizované elektronické efekty navazování protilátek na nanokompozitních materiálech (LEEFAB)</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
—
Svazek periodika
28
Číslo periodika v rámci svazku
20
Stát vydavatele periodika
AE - Spojené arabské emiráty
Počet stran výsledku
10
Strana od-do
3925-3934
Kód UT WoS článku
000680008900003
EID výsledku v databázi Scopus
2-s2.0-85109117514