Genetic polymorphism of Myf-5 and myostatin in Charolais breed

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F09%3A00010754" target="_blank" >RIV/60076658:12220/09:00010754 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genetic polymorphism of Myf-5 and myostatin in Charolais breed

Popis výsledku v původním jazyce

The production of animals with superior muscle structure is of great importance to food animal agriculture. Muscle Regulatory Factors regulate skeletal muscle fiber development and postnatal hypertrophic growth. The genes of the muscle regulatory factors? gene family, consisting of 4 structurally related transcription factors - myogenin, MyoD1, myf-5, and MRF4. Myf-5 is one of four transcription factors belonging to the MyoD family that play key roles in skeletal muscle determination and differentiation. Myostatin acts as a negative regulator of muscle growth. Mutations in the gene are responsible for the double muscling phenotype in several European cattle breeds. We analyzed Charolais breed from Hungary. We used a PCR-RFLP method for genotyping Myf-5gene and myostatin Q204X mutation. These genes play an important role in the muscular development regulation. The heterozygous genotype was mostly representated in Myf-5 gene. As for myostatin, it was identified 10 heterozygotes in Q204X

Název v anglickém jazyce

Genetic polymorphism of Myf-5 and myostatin in Charolais breed

Popis výsledku anglicky

The production of animals with superior muscle structure is of great importance to food animal agriculture. Muscle Regulatory Factors regulate skeletal muscle fiber development and postnatal hypertrophic growth. The genes of the muscle regulatory factors? gene family, consisting of 4 structurally related transcription factors - myogenin, MyoD1, myf-5, and MRF4. Myf-5 is one of four transcription factors belonging to the MyoD family that play key roles in skeletal muscle determination and differentiation. Myostatin acts as a negative regulator of muscle growth. Mutations in the gene are responsible for the double muscling phenotype in several European cattle breeds. We analyzed Charolais breed from Hungary. We used a PCR-RFLP method for genotyping Myf-5gene and myostatin Q204X mutation. These genes play an important role in the muscular development regulation. The heterozygous genotype was mostly representated in Myf-5 gene. As for myostatin, it was identified 10 heterozygotes in Q204X

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Agrobiology

ISSN

1803-4403

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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