Marine natural products: Bryostatins in preclinical and clinical studies
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F14%3A43885594" target="_blank" >RIV/60076658:12220/14:43885594 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16370/14:43871807
Výsledek na webu
<a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >http://dx.doi.org/10.3109/13880209.2013.804100.</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/13880209.2013.804100." target="_blank" >10.3109/13880209.2013.804100.</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Marine natural products: Bryostatins in preclinical and clinical studies
Popis výsledku v původním jazyce
Bryostatins represent an important group of pharmaceutically promising substances. These compounds are produced by commensal microorganisms naturally occurring in marine invertebrates, mainly in bryozoans. The most frequently investigated substance is bryostatin-1, which is a highly oxygenated macrolide with a polyacetate backbone. Objective: The aim of this work was to summarize documented preclinical and clinical effects of bryostatin-class compounds. Methods: A literature search was made of Medline and Web of Science databases in 2012. Results and conclusion: Our review showed that bryostatins are potent agonists of protein kinase C. In addition to this, their significant antineoplastic activity against several tumor types has also been establishedand described. Bryostatin's anticancer activity has been proved against various cancer types. Moreover, significant results have been achieved by using bryostatin-1 in combination with other therapies, including combination with vaccine t
Název v anglickém jazyce
Marine natural products: Bryostatins in preclinical and clinical studies
Popis výsledku anglicky
Bryostatins represent an important group of pharmaceutically promising substances. These compounds are produced by commensal microorganisms naturally occurring in marine invertebrates, mainly in bryozoans. The most frequently investigated substance is bryostatin-1, which is a highly oxygenated macrolide with a polyacetate backbone. Objective: The aim of this work was to summarize documented preclinical and clinical effects of bryostatin-class compounds. Methods: A literature search was made of Medline and Web of Science databases in 2012. Results and conclusion: Our review showed that bryostatins are potent agonists of protein kinase C. In addition to this, their significant antineoplastic activity against several tumor types has also been establishedand described. Bryostatin's anticancer activity has been proved against various cancer types. Moreover, significant results have been achieved by using bryostatin-1 in combination with other therapies, including combination with vaccine t
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP503%2F12%2F0337" target="_blank" >GAP503/12/0337: Invazní mechovka Pectinatella magnifica v České republice: její biologie a sekundární metabolity</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pharmaceutical Biology
ISSN
1388-0209
e-ISSN
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Svazek periodika
52
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
237-242
Kód UT WoS článku
000329301800016
EID výsledku v databázi Scopus
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