Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F21%3A43903346" target="_blank" >RIV/60076658:12220/21:43903346 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.mdpi.com/2076-2615/11/12/3594" target="_blank" >https://www.mdpi.com/2076-2615/11/12/3594</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ani11123594" target="_blank" >10.3390/ani11123594</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland
Popis výsledku v původním jazyce
Bovine mastitis (inflammation of the mammary gland) is still an important problem for dairy farmers. This disease causes great financial losses across the world. The common method of treating mastitis is through the use of antibiotics. Antibiotic treatment should be minimized because of increasing antibiotic resistance. Streptococcus uberis (S. uberis) is one of the most important pathogens that causes bovine mastitis. This bacterium is able to hide and survive inside of epithelial cells. In this situation, antibiotic treatment is not efficient. Therefore, it is necessary to study the pathogenesis of mastitis that is caused by S. uberis to better understand how to treat this disease. In this study, we investigated a special type of lymphocytes-gamma delta T cells. The results of our study show that those cells may play a role in terminating inflammation in the mammary glands of cattle. In this study, we focused analyzing gamma delta T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The gamma delta T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that gamma delta T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.
Název v anglickém jazyce
Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland
Popis výsledku anglicky
Bovine mastitis (inflammation of the mammary gland) is still an important problem for dairy farmers. This disease causes great financial losses across the world. The common method of treating mastitis is through the use of antibiotics. Antibiotic treatment should be minimized because of increasing antibiotic resistance. Streptococcus uberis (S. uberis) is one of the most important pathogens that causes bovine mastitis. This bacterium is able to hide and survive inside of epithelial cells. In this situation, antibiotic treatment is not efficient. Therefore, it is necessary to study the pathogenesis of mastitis that is caused by S. uberis to better understand how to treat this disease. In this study, we investigated a special type of lymphocytes-gamma delta T cells. The results of our study show that those cells may play a role in terminating inflammation in the mammary glands of cattle. In this study, we focused analyzing gamma delta T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The gamma delta T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that gamma delta T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
40201 - Animal and dairy science; (Animal biotechnology to be 4.4)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Animal
ISSN
1751-7311
e-ISSN
—
Svazek periodika
11
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
3594
Kód UT WoS článku
000735280800001
EID výsledku v databázi Scopus
2-s2.0-85121296766