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Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F21%3A43903346" target="_blank" >RIV/60076658:12220/21:43903346 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://www.mdpi.com/2076-2615/11/12/3594" target="_blank" >https://www.mdpi.com/2076-2615/11/12/3594</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/ani11123594" target="_blank" >10.3390/ani11123594</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland

  • Popis výsledku v původním jazyce

    Bovine mastitis (inflammation of the mammary gland) is still an important problem for dairy farmers. This disease causes great financial losses across the world. The common method of treating mastitis is through the use of antibiotics. Antibiotic treatment should be minimized because of increasing antibiotic resistance. Streptococcus uberis (S. uberis) is one of the most important pathogens that causes bovine mastitis. This bacterium is able to hide and survive inside of epithelial cells. In this situation, antibiotic treatment is not efficient. Therefore, it is necessary to study the pathogenesis of mastitis that is caused by S. uberis to better understand how to treat this disease. In this study, we investigated a special type of lymphocytes-gamma delta T cells. The results of our study show that those cells may play a role in terminating inflammation in the mammary glands of cattle. In this study, we focused analyzing gamma delta T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The gamma delta T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that gamma delta T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.

  • Název v anglickém jazyce

    Effect of Streptococcus uberis on Gamma Delta T Cell Phenotype in Bovine Mammary Gland

  • Popis výsledku anglicky

    Bovine mastitis (inflammation of the mammary gland) is still an important problem for dairy farmers. This disease causes great financial losses across the world. The common method of treating mastitis is through the use of antibiotics. Antibiotic treatment should be minimized because of increasing antibiotic resistance. Streptococcus uberis (S. uberis) is one of the most important pathogens that causes bovine mastitis. This bacterium is able to hide and survive inside of epithelial cells. In this situation, antibiotic treatment is not efficient. Therefore, it is necessary to study the pathogenesis of mastitis that is caused by S. uberis to better understand how to treat this disease. In this study, we investigated a special type of lymphocytes-gamma delta T cells. The results of our study show that those cells may play a role in terminating inflammation in the mammary glands of cattle. In this study, we focused analyzing gamma delta T cells during bovine mammary gland inflammation induced by Streptococcus uberis. A mammary gland cell suspension was obtained using lavage 24, 48, 72, and 168 h after intramammary-induced infection. The proportion of lymphocytes increased during the entire week in which inflammation was present. The gamma delta T cells were also elevated during inflammation, reaching their peak at 72 h following induced inflammation. The percentage of apoptotic lymphocytes continually increased, with the highest proportion occurring 168 h after S. uberis infection. The results show that gamma delta T cells may be involved in the resolution of inflammation in bovine mammary glands, with the apoptosis of those cells potentially playing an important role.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Animal

  • ISSN

    1751-7311

  • e-ISSN

  • Svazek periodika

    11

  • Číslo periodika v rámci svazku

    12

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    8

  • Strana od-do

    3594

  • Kód UT WoS článku

    000735280800001

  • EID výsledku v databázi Scopus

    2-s2.0-85121296766