Role of adipokinetic hormone during starvation in Drosophila

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897536" target="_blank" >RIV/60076658:12310/18:43897536 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/18:00492457

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S109649591830099X?token=D20B5E642F6264CC582C44D82F5DF988823D6636B5843CA0DE38DECDFF72CFC0970A5DD3A11A806F4DD01BFA4B07A440" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S109649591830099X?token=D20B5E642F6264CC582C44D82F5DF988823D6636B5843CA0DE38DECDFF72CFC0970A5DD3A11A806F4DD01BFA4B07A440</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbpb.2018.08.004" target="_blank" >10.1016/j.cbpb.2018.08.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of adipokinetic hormone during starvation in Drosophila

Popis výsledku v původním jazyce

The role of adipokinetic hormone (Drome-AKH) in maintaining the levels of basic nutrients, under starvation conditions, was studied using Drosophila melanogaster mutants with AKH deficiency (Akh(1)) and AKH abundance (EE-Akh). Our results showed lipids as the main energy reserve in Drosophila, and their physiological level and metabolism were shown to be under the control of AKH. AKH abundance in the body resulted in lower levels of triacylglycerols and diacylglycerols than in the controls, probably due to a more intensive metabolism; interestingly, there was a disproportional representation of fatty acids in triacylglycerols and diacylglycerols in Drosophila. Lower level of glycogen and its partial control by AKH suggest its lesser role as the storage substance. However, maintenance of free carbohydrate level in Drosophila seemed to be critical; when glycogen stores are exhausted, carbohydrates are synthesized from other sources. Protein levels and their alterations, under starvation, did not seem controlled by AKH. AKH-deficient flies were more resistant while AKH-abundant flies were more sensitive to starvation; females were found to be more resistant than males, regardless of the AKH level, probably due to higher body mass and higher amount of nutrients. However, in accordance with the level of all nutrients, that of AKH also gradually decreased with prolonged starvation.

Název v anglickém jazyce

Role of adipokinetic hormone during starvation in Drosophila

Popis výsledku anglicky

The role of adipokinetic hormone (Drome-AKH) in maintaining the levels of basic nutrients, under starvation conditions, was studied using Drosophila melanogaster mutants with AKH deficiency (Akh(1)) and AKH abundance (EE-Akh). Our results showed lipids as the main energy reserve in Drosophila, and their physiological level and metabolism were shown to be under the control of AKH. AKH abundance in the body resulted in lower levels of triacylglycerols and diacylglycerols than in the controls, probably due to a more intensive metabolism; interestingly, there was a disproportional representation of fatty acids in triacylglycerols and diacylglycerols in Drosophila. Lower level of glycogen and its partial control by AKH suggest its lesser role as the storage substance. However, maintenance of free carbohydrate level in Drosophila seemed to be critical; when glycogen stores are exhausted, carbohydrates are synthesized from other sources. Protein levels and their alterations, under starvation, did not seem controlled by AKH. AKH-deficient flies were more resistant while AKH-abundant flies were more sensitive to starvation; females were found to be more resistant than males, regardless of the AKH level, probably due to higher body mass and higher amount of nutrients. However, in accordance with the level of all nutrients, that of AKH also gradually decreased with prolonged starvation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Comparative Biochemistry and Physiology B - Biochemistry &amp; Molecular Biology

ISSN

1096-4959

e-ISSN

—

Svazek periodika

226

Číslo periodika v rámci svazku

DEC 2018

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

26-35

Kód UT WoS článku

000447114400004

EID výsledku v databázi Scopus

2-s2.0-85051656925