Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F19%3A43899520" target="_blank" >RIV/60076658:12310/19:43899520 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/19:00508104

Výsledek na webu

<a href="https://science.sciencemag.org/content/365/6460/1457" target="_blank" >https://science.sciencemag.org/content/365/6460/1457</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/science.aax1318" target="_blank" >10.1126/science.aax1318</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

Popis výsledku v původním jazyce

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

Název v anglickém jazyce

Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests

Popis výsledku anglicky

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10616 - Entomology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science

ISSN

0036-8075

e-ISSN

—

Svazek periodika

365

Číslo periodika v rámci svazku

6460

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

3

Strana od-do

1457-1460

Kód UT WoS článku

000488838600049

EID výsledku v databázi Scopus

2-s2.0-85072710875